NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

Terry: Regarding Chemo and the Immune System

I looked around the internet some months ago for articles on the effects of Temador on the immune system. I came across the article below that claims that at least in "many cases" there is substantial damage to the immune system from Temador during SOC for GBM with progression apparently occurring because the immune system has been so damaged.

It would have made sense for Merck to have settled on a GBM Temador regimen where there is typically a balance between the damage the Temador does to the Tumor, and the damage it does to the patient. At least, that makes sense to me. Actually the right thing to do. But if so, I don't think that the same Temador regimen would allow that balance when you add an adjunct, such as DCVax-L, or even Avastin. Not transparent to me, but using my foggy-logic radar, I'm pretty sure that the optimum amount of Temador in that case would be somewhat less.

Whether the damage that Temador does to the immune system is permanent or not, apparently in many cases, it is enough to allow progression, and death. At least according to the article below.

The moral that I get out of this is that however well DCVax-L is working, it might work even better with the simple change of reducing the number of cycles of Temador. You would think that the methylated patients could afford to role that back even a little further than the rest. Ie, that the optimum Temador regimen for them would be a little less still.


(Temador Immunosuppression Problems)
http://www.ncbi.nlm.nih.gov/pubmed/21737504