Replies to post #11013 on NorthWest Biotherapeutics Inc (NWBO)

[hodge14]

Dok - It's my understanding that high fevers are the norm for patients and expected. Without going in to great detail, the 3rd injection resulted in a lingering fever for a week or so. All 3 have initiated fevers and one was her highest ever (104.2). It also didn't associate itself with body aches, but maybe in others it does. (My wife approves this message...and reads this board)

I hope that helps.

[terry hallinan]

Doktor,

I do know someone with lung tumor that were "killed" by radiation and chemo whose been told the necrotic tumors may never go away. Not sure he used the term necrotic

My father had broken his leg again playing Irish football. After the x-rays had been taken the doctor was giving Dad the old "does it hurt now" routine. Dad, who should have been having his head examined at his age playing Irish football, asked why he was still being put through the "does it hurt" routine. The doctor told him all the old breaks showed up with the new break and they couldn't tell which one was new.

X-rays are perhaps much superior and doctors more skilled in interpreting them but maybe the doctor was describing scars rather than remaining tumor. Just a suggestion.

Doc Adams: We have to get that bullet out but the operation could kill him.

Marshall Dillon: That would save us from hanging him but why do you always need to get that bullet out?

Why indeed? Because of some threat of one kind or another, doctors today may leave the bullet in place whatever the barber/blacksmith/dentist/surgeon of yesteryear did. But even though lead slug is encapsulated by the body, it still presents a threat with lead still being leached out into the body. No good answers to some things.

I wonder whether those severely hindered (or dead) tumors would go away if he was not receiving regular chemo. Between the radiation and continued chemo, his immune system might be greatly impaired.

In this case, the radiation and chemo worked. He has been functional for years this way. Though he does have major scarring from the radiation. And the monthly (I think it was monthly) chemo makes him pretty weak for a few days after.

I am hopeful that DCVax-Direct finishes the job.

The immune system seems capable of taking horrendous punishment. Alternation between chemo and immunotherapy seems to take only a week or two for the immune system to recover sufficiently. Surely I agree it must be hard to undertake continuing treatment. You don't think the price of the treatment has anything to do with the need do you? Nawww that couldn't be. :-)

BTW Parke-Davis rechristened Coley's cocktails as Coley Fluid. See:

http://books.google.com/books?id=iKT7ElBjLOgC&pg=PA5&lpg=PA5&dq=parke+davis+coley%27s+cocktails&source=bl&ots=TBzHYR2p2O&sig=ke86N2uMd7Mwr7Zt59b7FJqQ6Q0&hl=en&sa=X&ei=oB1_U9LrG-.LJsQSu0YGwDA&ved=0CDMQ6AEwAQ#v=onepage&q=parke%20davis%20coley%27s%20cocktails&f=false

Nobody but nobody would have ever told patients they were being given Coley's Toxins. That is pure invention. That the stuff was toxic like many drugs should go without saying.

Best, Terry

[geofusion]

Dok, I think I can offer some info on necrosis. My nephew had Medulloblastoma, similar but not as bad as Glioblastoma. They did surgery to remove the largest tumor from his brain stem. After that, he had successful radiation and chemo treatments. On one of his follow up MRI's, the found a couple of little things. Turned out to be necrosis thankfully. The dead pieces of small tumors in his spine were of no concern to the doctors once they were sure the cancer was not active. So, I would assume any necrosis would not be a worry unless it is so large as to cause other symptoms/impairments. Hope that helps.