Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
ok, I will bite. The references are from what?
Or was it last week? Or last month? Good luck
Just you wait until Monday when this thing is just gonna blast off way up into the sky. With news that will strike like a dagger deep into the hearts of the enemies of IP. In other words the dagger will go in but the stock will go up up up
Or maybe next next Monday.
Or ...
Let me see- the BIG BIG grant submission was 4 months ago and we heard back about that when?
Oh yeah- never.
Post of the year. For those who have paid any attn. LOL, seriously.
It's so good all good isn't it. Just keep on with the amazing in the lab tests that show how great B v C is. In a some lab somewhere. When in reality ALL THAT COUNTS is the trial showing benefit in patients.
Too funny. Sure, keep on testing in the lab, why not, and never move forward. That's good news, right?
Sigh....
Filo and alpha and SARS, oh my- RBL and IP collaborate on what exactly? For real, or for show? Agree- PR award not submission
Filo and alpha and MERS , oh my, chanted the crowd, waiting for the carnival man to emerge on Oct 11, the four month anniversary of the big pan corona plus others viral research grant pushed by the RBL and IP. On June 11 the announcement seemed so real, so upbeat, so enticing. Many in the crowd had purchased shares in the company, and the common had printed up millions of them. It seemed exciting at the time but as the days wore on, people began to wonder if they had been duped.
Because the company man dropped the whole grant thing entirely. Gone.
We wanna know what happened, the crowd said. We want know if you made the whole thing up. We bought our shares fair and square and we deserve to know now.
But the carnival was not pausing for any explanation, or clarity, not even a bit.
Instead the man told the crowd that they kept doing more and more research because it was going so well- heck, they woulda stopped months ago if it were no good, he said- and that some day they would put it out for everyone to see. They would publish. Focus on those peer reviewed articles, almost ready, just hang on. Things were not published because so much good stuff was being done they just had to keep doing more. But the articles would come out, so get in line and get a part of the future of medicine
Some people thought that was one of the dumbest things they had ever heard- the corona virus had shut down the world and was killing people, but instead of putting out some information and starting a trial, they kept doing lab work. And then the article did not not come out
But the man said that very soon the trial would start, hard to say when, but it would and they were planning meetings with the FDA. Forget the grant and the papers, the trial would have 120 sick patients and hospitals all over the country were just begging to be part of it, calling night and day. Hospitals and doctors cannot wait to try Brilacidin and you are in the very right place at the very right time
And that was enough for a lot of folks. The company was printing millions of more shares and the people could buy some of them too and think about the trial changing the world, just around the corner, and if you got two dimes well, then you can step right up and buy in.
The grant and the papers were forgotten by most of the crowd and they gathered up their change and bought few more shares. They forgot their anger and waved signs, Defensins are your Friends! and Synthetic Molecules R Us! Their anger cooled just as did the season and the beautiful fall colors in New England helped them forget any disappointment. They no longer chanted about MERS and SARS.
They were sure the world was just about to change, any minute now.
Any minute.
Riddle me this: RBL well aware that COVID therapeutics need help. Do they need to do additional study , just one more? Or do they need to start the trial already. If they have a dose in mind, as they said already, and that dose was OK for 500 people, let me think...start the trial.
If B v C is so promising, start the trial already
Sept will be HUGE! Now it is Oct! Huge , I tell you. Right. How about November?
Critical failure to get data out to move forward. IP issuing its chance now, right now.
Actually they needed data out a month ago. It's slipping away, folks
NEJM 10/8 MERS article . Did you say MERS? Like the corona virus CEO referred to four months ago already>. As a B target? And one of the reason RBL and IP would submit a grant together?
Yikes - so much for an update...
Meanwhile , in the real world, NEJM has an article on new therapy.
Where, oh where is B?
recall folks: we are advised it is GOOD NEWS there are delays in data. Good because it means they want to do more and it must be going well.
Is this the most obvious nonsense? or what? Get a move on IP you are losing out.
Trial trial trial is all that counts and every single day with no prepublication is another dagger in the heart of IP as other therapies move forward and B does not. Now we have a MERS trial in the NEJM. When does the B MERS testing start? Gee, I don''t know. And neither does anybody else. Could it be that the CEO thinks we are all morons, and do not care, or we are demented fools who have forgotten a critical PR 4 months ago??
Gee whiz. I mentioned my wife to explain that in fact I do know something about the NIH grants process. Get over it
Totally on topic. It is about the 4 month wait for a grant update, announced in the 6/11 PR form IP. It is about the B OM subsets of data, also released as a PR from IP.
How much more on topic can you get?
Sir:please note that the main comedy provided for IP is by management, and others need not bother, really. Might I direct you to the spring 2019 B OM subset data? Try reading through that ridiculous nonsense without a smile. Just try. Such big claims for small meaningless numbers.
Now that is comedy, although the laugh is on us shareholders.
The four month wait to which you refer, since the FABULOUS 6/11 PR, has not yet reached the level of comedy.
Instead, it remains tragic.
At some point MERS and SARS and filo and alpha will indeed bring a smile to any concerned party- how did we ever fall for that?
But no, tragedy still.
Shareholders made plans to gather again off Route 128 just north of Boston to mark the 4th month anniversary of the big June 11 announcement, the PR where a breathless CEO told his shareholders, and the world, that the RBL would apply for a grant with IP to study COVID but also, MERS and SARS and other viruses, filo and alpha, for example.
This was exciting, and many were induced to part with hard earned cash to be a part of this company with a revolutionary synthetic molecule therapeutic.
Some will be wearing I'm a B-liever T shirts and caps and there are a variety of custom license plates, BRLCDN- just one example, spotted here around Wakefield.
There were those who ventured to Beverly MA as well, standing around an empty office, the less well-informed, one suspects, although the shareholders still pay the rent for that space too. (Now that's a laugh)
They wanted to see what the carnival barker had to say about progress on the federal grant that sounded so great. But now it was 4 months already and there was no news. Was it a scam, they wondered, as they eased off the exits?
More to follow....
Also won't call about the CIA or the BBC Dig it-
TIAB also don't wanna bother to phone Leo about the BIG BIG grant he brought up 4(4!) months ago. He just won't call. Not about the trial or the RBLs or the FDA the grant or whatever he could but he won't. He don't.
Hmm. I do write frequently, just to remind the CEO that we company owners deserve followup on a little bitty item like a grant to investigate B vs MERS and SARS and all those other troublesome pesky viruses.
NB: ideal IP shareholder prefers ignorance- because your CEO keeps us all in the dark.. Don't tell. Don't ask.
Don't worry, don't fret. These answers will all be known...in the coming weeks. Just like they were all going to come out in the HUGE month of September. So now it's October. When it all comes out. Until someone mentioned November yesterday. That is also plausible
In other words don't hold your breath as other companies actually move forward with therapeutic options and govt money
Yes it is pathetic
My shift was just finished, thank you. I notice you have no rebuttal for my supposed disinformation, other than to say it might work.
I said many times that B v C might work. It might.
And it might not. You have already stated the obvious: lab data may or may not translate into actual patients.
The homework is not mine to do. The RBL has done homework on someone's suggestion- DeGrado's? And from what we know- very little indeed-B has antiviral activity. We have no specifics because we have no data yet, except a few conclusions provided by IP.
My guess is that there is no difference in our views at this point: the trial is what matters. Other than you have more of a stake in the game, a lot more shares.
I would be happy to have DeGrado as Person of the Year and B as Synthetic Molecule of the Century if all goes well, and we can meet back here in 4-6 months if IP can get things moving
This is a nice summary. Let's think about it.
1- B already given to a lot of people. This is a BIG positive as you note. Given SAFELY to hundreds of people. They did not have corona virus(which is why I was wrong to think Trump would get it) and who knows about potential adverse effects...but a big plus agreed -
2-11,552 MOA stuff- who the heck knows. Maybe just the critical interaction to stop the virus and maybe worth nothing. Any biochemist would tell you they do not know. DeGrado(UCSF Pharma Chem) would tell you he does not know. Not even a clue-
3- 3 in 1. Sorry. Maybe key, maybe not. Antiinflamm dosing- tell me pls the selectivity index for this MOA. Having difficulty? That is because no one has the slightest clue. A total unknown. Also, BTW, unknown, if any impact above and beyond dexamethasone, which will be a part of any trial if the patients selected are very sick. Maybe they will not include such patients in a trial, for good reason. Where is the B/Dex in vitro data, like the B/Rem in vitro data? Hmmm.
4-3 in 1 again Please do not try to convince me that really sick potential trial patients will not be on antibiotics- they will. Every one of them(that is what doctors know how to do). So it remains to be seen.
Can they find their 120 patients not on antibiotics and not on steroids? Of course they can. Not the sickest patients, not at all. But these would be the patients who might benefit from B. So, let's say instead they are looking at 2 in 1: anti viral and anti inflammatory and admit that antibacterial effect = already very easily covered by every hospital in good old USA.
All the rest of your points- not bad, but let's see how B v C works in a trial of actual patients and not in a lab. That is ALL THAT WILL COUNT. Yes I like - very much - the B/Rem stuff(caveat: we have ZERO data....just like so much of what Leo touts, sad isn't it?)SO it all remains to be seen.
Fingers crossed.
Await pre-pub.
Await trial.
Await a grant- seriously, c'mon IP and tell us more....MERS and SARS and etc...was it real? Or what? It just kills me that CEO will not update. It is BOGUS!
As I said I tend not to believe in miracles but hope to be wrong here. In fact I just picked up many thousands of more shares because I believe at least short term is optimistic .
Long term, well, it'd be a miracle for B v C success
I for one do not expect B for C to save the company. I still believe it is more likely than not to fail in the trial. That may in turn use up any money the company might have used for the B UC trial, which I thought had a good chance of success.
trial success = deus ex machina, not RBL in vitro success
it will be a shocking and unexpected miracle if B beats C in a trial. I find it hard to believe that life is like that- lottery tickets do not pan out, and that is what the chances of B for C are most like. Exciting and amazing thus far, and who knows, it might even work.
I wanna believe since it would help my financial outlook, hard hit by 4 kids and college.
But generally miracles are hard to come by and this would be one.
always something about to happen always next week never now never right now don't look away
always plenty of buying opps never any news after early morning never a need to watch for big developments if no news by 9
something big is coming any day now simmering just around the corner
really? Like when?
How great would it be to have B become a standard of care treatment? And let other potential drugs show a benefit above and beyond B alone? The time to strike is now.
In fact it was a month or two ago, truth be told
I'm a B-liever for many years already. I will state the obvious. If B v C is a winner it'll be sensational. But every day that goes by is a problem now. Take one purported MOA of B v C- modifying the inflammatory response. Any trial now must give patients dexamethasone if they are sick enough, in addition to B. Can B find plenty of patients admitted but not sick enough for steroids ? It gets more complicated as more therapeutics prove beneficial. Once their benefit is accepted as proven, it will be unethical to have a trial and not give that drug to a patient. Does B have a benefit beyond dexamethasone? In addition to? It'd be easier to show benefit with this MOA without the patient already getting a steroid. Do I know this for sure? Of course not, it's a total guess. But anyone will tell you that steroids are big inflammatory guns and MAY muck up the water for B inflammatory MOA. Is it possible that B + dex is wonderful and marvelous and synergistic and will be the standard of care 6 months from now? Yes yes yes.
And yet As week and months progress that patient population will be on more drugs that show some benefit. It just gets messier.
Is it worth worrying about? Who knows. Preemptive strike by RBL, right? B plus Remdesivir looked better in a lab than Remdesivir alone. Have they done the same study with dexamethasone+ B? And how many other drugs will become standard of care before B is ready to go in a trial?
Time is wasting' Leo, fellow shareholders.
November prepublication ? Had I written this, it would have been dismissed as seditious propaganda! But here received and purported to be good news.
Let's be serious for a minute. If there is no grant news and no data out from RBL until November- nothing for a month, maybe -then what will the share price be?
It will be a scary Halloween share price if Leo cannot tell us about the grant and the RBL(and PHRI?) release nothing.
Challenge, anyone? "high likelihood of success" of B v C in a human trial? Or pretend it is true? Surprising that this false perspective is allowed to stand
Just one opinion. So why not? My own contrary opinion is only one opinion too.
RBL and PHRI articles...hmmm. Back the to the June 11 PR. Stated there that there will be separate articles form the RBL and the PHRI
That was, let me see let me see, 4 months ago. And then the blockbuster June 17 human lung cell announcement in the next PR.
So they had key data already done and wrapped 4 months ago and we are told that it is so wonderful that they are still working on extra in vitro stuff so sit and wait
Seriously? Really? No. It would be better to have published what they could a month ago, say stay tuned, more to follow, and get moving with the trial and the FDA.
And what about separate articles? Is that still true? Of course we have no clue because it is never explained to little bitty you and me the company owners the shareholders.
Not to mention the grant, the much larger scandal from June 11- no news about that big grant since.
Trial start more important than extra B v C in vitro data- agree. Took a long time to say it, no?
I think prepublication one month ago and getting on with the trial woulda been much better approach
More delay is better, then? Complete nonsense when taken to an extreme of course, with infinite delay. Obv needs to be some better time to be done with enough info to get out results. So when is it time to prepublish? Or, when was it? I would argue starting the trial is a lot more important than getting more in vitro data.
Is it fine to see an article in November ? Does that leave time to meet with the FDA and start a trial? If they know the dose, and supposedly they do, why isn't a week or a month ago a much better time to publish what they had and moved forward with the trial.
Since the trial is all that counts anymore
Sure it's nice to believe that more tests =more confidence in B v C, and it must mean that, it makes plain common sense. But they also need to keep in mind DHHS OWS and CTAP goals. Do those count at all? Getting trials started now, this fall, so that manufacture can ramp up if there is success? I think getting a trial started is a lot more important than adding more bits of data to the B v C story
Actually it was a salute to Prince. Let's go let's go. crazy . Never spent much time on the Cape, sadly. yes NC native UNC grad - another let's go reference
Let's go Tar Heels
does anyone believe this? Pre pub will result in a stir if data are good, and if a big journal accepts. Trial announcement will help.
Big grant for MERS SARS etc etc would be so excellent but it ain't happening
Share price maybe a double or triple in the short term but no rocket until trial results out
Maybe successful, maybe not-let's go crazy Leo. Turn it up already.
Let's go let's go
Crazy
I know something about grants My wife reviews NIH grants, and writes and gets them
Plus: these are expedited grants that we are talking about. Not your average everyday timeline
Leo knows something he is not telling us, that is for sure
It may be as simple as: no grant until prepub out
If true, then SAY it already
You calling it shady to talk the big talk four months ago and then not say a word more about it? Like it never even existed? All those viruses and the grant to study them?
Well, it is shady, ain't it?
The IP CEO owes shareholders an explanation- for sure
Should we just pretend it never happened?
The big words from June 11 never materialized into anything, It was if they were never spoken. Some small voices asked about that federal money grant and all that excitement over the treatment of so many viruses and why after so many months the company man would never talk about it again.
Sucker, some said, fool. Don't you realize that you got conned out of your money? Can't you figure that out?
But others said forget the grant, who cares, we believe in the big corona trial and who even cares about a grant anyway that was a long time go
But the man thought it was wrong to forget the big talk- it amounted to lies to get him to buy shares in the company. If someone lies to you once, won't they lie to you again?
The carnival man knew in June and in October what to say to keep the carnival crowd's attention. He knew their memories were short and they had hopes for a big gain from small change
"Hey friends. Got two dimes? I can sell you a share from my company, a company that may change the world. That corona virus that you hear about- wait till you see what we have coming...it's a synthetic molecule and it was designed by computers and I can sell you the future if you can see it.
After the carnival barker made all those promises and took the money from those people who reached into their pockets to share in the dream of anti viral research going in so many directions, so promising, with federal money- after taking their money after all those big words that was it-
on to other topics just like the grant never existed. Like the June 11 speech was never made. Like it was just a dream. And if people wanted answers, well, there were new promises to talk about and you could buy into that too if you did not want to be left behind.
The carnival barker was no fool, but he realized that others were, and you could take their money and never even have to answer the simplest questions about big talk from 4 months ago...
What grant? Let's talk about a trial, how about that instead...I have got some more shares and you can be a part of this therapeutic revolution.
More later...
Four- count 'em four-months ago the carnival barker set up shop near Route 128 outside Boston and a crowd gathered. They came to hear about the battle shaping up that could change the world- a synthetic molecule called Brilacidin versus the corona virus, a global pandemic causing panic and fear.
On June 11 the company man spoke to the people who had gathered there. "The RBL and I are collaborating on a grant to study B for C, but that 's just the beginning. The grant is to study brilacidin and other corona viruses, like SARS and MERS too.
"But that is not all. Not by a long shot. The grant will be to study brilacidin and other viruses alpha, and filoviruses. Do you hear the words that are coming out of my mouth? I am telling you that a government agency lab is telling me that I should apply with them for a federal grant to study many types of viruses because they are so excited about our shiny new synthetic molecule.
"I am giving you the chance to join me and them right now. I am issuing new shares in my company- lots of new shares, in fact millions of them, to give YOU the chance to own a part in all this. And it only costs a nickel and a dime or two to buy in."
He knew the pitch was good because many people reached into their pockets and pulled out their change and bought shares right there on the spot.
But what would happen four- count 'em four-months later? When the carnival barker never said another word about that big federal grant to study all those viruses? After he took the money but dropped all that talk about MERS and SARS and filoviruses ? Can the carnival barker just pretend all that talk never happened? Even though he took their money?
To be continued....
"Are you playing us for suckers, Mr CEO?," said a small voice at the back of the carnival crowd." I was reading back over that June 11 PR, you know, FOUR months ago. You said you were submitting a grant that would use B for COVID but much more. So much more- you mentioned SARS and MERS and alpha and filoviruses as targets for brilacidin, and it all sounded so exciting ? Remember that sort of talk?
" I bought more shares in your company after I read all that. But that was 4 months back already. What is going on with the grant to study brilacidin and all those other viruses.
"30 and 60 days out I was not worried about a lie. But now after four whole months and you saying nothing, nothing at all- well what do you have to say?
"Are we just suckers? Why cain't you tell us the truth? I bought into your company and we deserve to know."
Others in the crowd shifted uneasily, as they recognized the plain truth of the man's words. So much was promised, and then abandoned.
Stay tuned...
Carnival barker tease ? IP- the perfect company to own if you prefer your big news to come next week. Because it's never today, or this week. It's never when its needed, such as a month or two ago.
Think RBL data and prepub-
Think grant announcement-
IP = tease, only, so far. Carnival barker says, step right up folks, the initial data, B vs C, is so good that I am submitting a grant for other corona viruses and other viruses in fact.
That's how good B is, ladies and gentlemen. Pan corona research, but not just corona. Think about other viruses too- there are lots of them out there In case you did not know. B may very well destroy them as well.
If you insist on waiting for the grants to come, you may miss out. What an opportunity, folks. Get in now with a revolutionary approach to medical therapy, get in now for pennies!
Some of you will wonder where the grant is, and where is the supporting data, and can you tell us a timeline and stick to it.
And I say buy in today for pennies and you can own the future, the future of medicine, as our synthetic molecule not only kills bacteria, but viruses too, and plenty of them, not just the pandemic corona virus.
Step right up folks!
When will IP and Leo step up with real data or a real grant? How much of this is just a show?
I am inclined to think that those who argue that Trump will not get B before others get it in a trial setting is correct. It would be ideal if he could get it very early in his disease course- yesterday or day before woulda been very nice, I suspect for him(don't know for sure obv) and certainly good for all of us.
I was wrong to jump up and down about B for Trump until more is known, but we shall see.
Thanks for your very helpful info about eyes on IP/B-
OK re thought it. You are probably right- someone needs to be the first patient, just not the President
I do not see why not. Safety in so many other people already clear. Sure I realize they did not have COVID. How many corona patients have been given the Regeneron drug? I shoulda looked up first but it is not many.
You may be right though- to be sure not some odd reaction