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Company survival is at stake. if B v C fails then the IBD indication was a KEY remaining focus. If oral B is now in doubt then the company may not survive B v C failure.
Oh yeah sure- trial will go on B UC in 2022. As if. All bets are off.
Medically: Crohns = oral to anal problem as opposed to UC which is a problem mostly for the colon. Both diseases have important manifestations outside the GI tract, involving other organs.
So would any immed release oral B reach the colon? We do not know.
Presumably some Crohns patients might benefit if the have more proximal disease- small intestine etc.
But the original thinking was that a sustained release prep would be necessary or there would never have been all that focus on finding the right formulation.
Again: this is a very big deal for the company.
who failed here? Leo or us? He hyped B for IBD over and over and was only too happy to talk about the IBD market and the phase 1 trial but then when there is trouble there is NO PR.
Leo failed to inform us in a reasonable way.
Clear and simple,
Did we as a group fail starting apparently in May? Maybe.
Is our job to look in every corner for Leo's burials of bad news?
Apparently it is. But he did not perform his job well, and did not treat this problem with the attention it deserves.
as I said- Leo has been yapping about IBD over and over and failed to announce in any meaningful way what happened.
Switching to immed release from delayed release AFTER the phase 1 and after those delayed release PRs- remember them???- is a big deal.
This is a real problem. And Leo hid it. In plain sight?
Not nearly so plain as all his other PRs about the topic.
Right?
It is totally bogus.
Delayed release oral B for UC is a debacle! Leo buried it the best he could.
After following just the opposite strategy prior for B v IBD- talk talk talk then BOOM- he mentions I a 10K- NOT a PR-that there are problems with delayed release oral B for IBD.
Luckily KMBJN noticed this in the current 10K, or else we would all be none the wiser.
This is very ugly business as usual from Leo- hide bad news.
How will he hide B v C results? No way out now, one would think, and failure is likely.
wake up people. You wanna pretend Leo did not bury the B UC delayed release problem? Of course he did. There has been ZERO discussion of the issue here till KMBJN caught it on this 10K.
Zero.
You know how much Leo as hyped IBD? A lot. Much hype. Much chatter.
But when there is a serious problem with his much talked about delayed release formulation, Does he owe it to us company owners to be more transparent on this issue? Of course he does. But he chose to hide it and this is very bad news to every shareholder here.
The potential for IBD is huge and the early success with proctitis- distal UC was encouraging. Yes, I know, no controls, so remain calm, but still encouraging.
This is a serious management problem coming from a CEO who hid the Prurisol data too.
not even close to accurate. AS deal is for distal UC only. Right? oral B would be for all other UC and for Crohns. Therefore all other IBD focus- with the exception of the already licensed rectal product-is in doubt.
It is a very big deal esp when your CEO has hyped and hyped B for IBD
so much hype from IP about IBD and UC. Lots of PRs.
So much hype from Leo and IP about delayed release prep for B for UC trial- PRs on signing the contract, and determining that the new formula ought to be safe.
You can look it up.
World market for IBD yadda yadda...
And then, very quietly, a whisper in a corner: by the way folks that vaunted hyped delivery system FAILED
For those who cannot appreciate what a problem this is, then you have not been paying attention. (and of course my fault too for not seeing it in June 10K
But folks this is the first that we have talked about this on this board and it is a big deal and a major failure and VERY WRONG for Leo to hide in this fashion when SO VOCAL about B v IBD already
It is a sad and pathetic revelation-
OK if B beat C then it matters less. But it would be a critical step for B: IBD is a big deal.
And B prob does not help vs COVID- sorry
precisely- that is why it is CRITICAL.C beat B, very likely-
The point here is not the so-called Jan 2022 trial start. The point here is with all the delayed release hoopla- do you remember aLL THE PR'S???- and then suddenly it does not work???
And Leo totally buries this critical info-
Then I am at fault for not reading and noticing. Thanks for pointing it out-
It shoulda been announced much more carefully with more info to company owners- me and you.
It is of critical importance.
Leo should have said more - much more- up front about this concern!!!
And guess what- required reading or not- this was BURIED!
Just try reading. Out loud if you want. Did you see what the 10Q says? About a very absolute key product for this company?
It is a BIG BIG BIG setback.
BIG.
This is a MAJOR problem.
Shocking revelation HIDDEN AWAY IN THE 10 Q. Pay attention here folks - this is very bad news. B for UC is- or is it was, now-a CRITICAL COMPONENT of any signs of life for IP
Very very big deal to announce something so important in such a dismissive fashion.
Leo has put me on ignore- fellow shareholders make your ANGER known to Leo- this is BOGUS
CRITICAL find- buried in the 10Q. Big big news - hidden from company owners- me and you-until this moment.
This is a major problem everyone.
Typical insult from Leo to hide this from the owners of the company.
Is anyone paying attn??? This is a CRITICAL find from the 10Q. The time and cash spent working on the long release B for UC- you all remember that, right?-may not be working out. All that chatter and effort with the delivery system and the drug availability-out the window? Buried in a 10 Q?
It will not be the end of the world if B beats C- and the data are conclusive.
HOWEVER, folks, this was the best hope for this company until 18 months ago when the moonshot for COVID took over.
UC was the last best chance for IP.
And now we are told that the delaYED RELEase tanked???
"Unexpected findings encountered"????
That is all we are told.
This is a big big problem for the company. It means there nay be nothing left to see here if the trial data fail.
B v UC? Nothing accomplished for 18 months.
total scam sham
The wake in Wakefield- coming soon, B for C, let's get ready to say a fond farewell to this most excellent adventure.
The end is nigh.
Mr Toad's wild ride almost over !!! What a long strange trip from Leo and IP-
Final countdown after an 18 month diversion. What else was done? One little thing with B UC??? No.
18 months lost to a valiant effort to combat COVID with nothing else accomplished in the interim
When Leo gets up his courage he will tell us it failed and we will be back in single digits and see if the company can survive to B UC testing
IF it works and B beats C (very unlikely)Putin will be giving it shortly across Russia
Putin let the COVID crisis develop even when his hospitals in Moscow and St Petersburg ran the trial?
And never peeked in on the data???
Right.
As if.
where is lots of compassionate use in Russia? Where? Not reported by Leo.
1000 a day dying there so where is B use??? Why not?
Because it failed
and if the trial failed? Irrational exuberance.
Right. The grant we never got this summer. The grant which reviewers thought B did not deserve.
The failed grant.
Sure, if the trial succeeds there will be a zillion grants.
But it must succeed.
Am I all talk? Good question. I should sell off all shares- too many-since there is a rise in share price, which is another pump and dump, in my view, a brief rise as the data reveal approaches. Since I strongly believe the trial failed, then I should be selling now.
Why not sell? Every last share?
I still hope that B UC will be winner, if the company survives.
But since I jump up and down about the price reaching a nickel do I sell today and tomorrow and buy back?
sure go ahead and buy then. but you could bet a lot more shares for your money in a month
about 7x more shares
LOL
Prurisol. Does anyone here remember Prurisol?
It won't be long now-
say what? no reason- one-for optimism here.
Leo will inevitably delay, then finally announce not good enough for prime time data. Just as in the past.
I hope to be wrong too- but it ain't happening. soon to be 5 cent
actually, headed for 5 lousy cents.
The only drama here is when Leo will fess up.
Complete and utter nonsense. What do you know, then? Nothing at all about the trial, since they have said zip. You either own an extremely valuable biotech commodity bought for pennies or you own junk.
So you do not know. And neither do I. We have opinions and that is all. My belief is that those who know a bit more have found out that C beat B in the trial.
So what is it that you know, then?
Hopes for a miracle and nothing more than a very very long shot at success
You misunderstand him totally. He would love to stand up as a hero to his country. But then you probably have never heard of geroy nashevo vremeni.
Your portayal of Putin is the one that is way way off. Sorry.
He found out it failed last May-
wrong then, but not now. Just one opinion, YMMV.
Putin knew it failed last June 1- count on it.
about 2 weeks away from net and I find IP at 35 cents. Why??? Results pending, that is all? There is NO reason to be optimistic here, folks. The news will very likely be bad, and I think we all know it.
You can buy back at 5 cents whenever IP bothers to reveal the truth about the trial.
How long will Leo drag it out?
Exactly. Life and death. Enough data back 6 months ago! And Putin and the FDA know it.
How big a fool do you suspect Putin is? His country is struggling and he is unaware they just finished a trial that would save lives and get people out of hospitals?
There is not even a chance that he does not know.
Putin znayet- hey, it's an uncomfortable and undeniable truth.
Konyeshno. (Of course.) Nothing could be more certain or obvious.
Nonsense. Efficacy life and death data woulda been known late spring for almost all participants.
Worth maybe a nickel when Leo finally gets around to telling his shareholders the truth. But when?
Can he drag it out till 2022?
Complete sham and joke in progress
Putin znal(knew) many months ago that B could not help the fight against C. The trial was done under his watch in his hospitals. He doesn't know if works?
Of course he knows. And it failed. Or it woulda been rolled out across Russia a very long time ago.