Replies to post #4223 on NorthWest Biotherapeutics Inc (NWBO)

[f3tt3f]

Great reading, but is this our DCVax she's writing about?

"As a result, with this unique qualities of IDO, DCs and siRNA, we orchestrated a novel intervention for immunomodulation of IDO by inhibiting with small interference RNA, called siRNA-IDO-DCvax. Proven that our DCvax created a delay and regression of tumor growth without changing the natural structure and characterization of DCs in melanoma and breast cancers in vivo."

[ou71764]

Thanks, John. When you said you got lost in parts of it, I knew I was doomed to miss big hunks of it.

I saw "holy grail" in your post and searched on it and found this thread about Sapacitabine, a non-related drug for leukemia.

But later in the thread, a knowledgeable poster was asked about NWBO's odds. The poster wasn't enthusiastic about NWBO's approach:

"I wish NWBO had chosen one protein, one antigen, and then really cranked up the immune system to go after it. Instead they are going for a nonspecific gmish of antigens, and so I think patients will get “nonspecifically” but not spectacularly better."

Was this discussed here before? I apologize if it was. If there's a prior post about it, perhaps you could point me to it. But I would appreciate comments from anyone who feels comfortable discussing the science. TIA.

http://www.stockgumshoe.com/reviews/biotech-supertrader/this-tiny-unknown-biotech-is-about-to-unleash-its-holy-grail-drug/