Replies to post #5326 on Amarin Corp Plc (AMRN)

[Whalatane]

Homebuilder
If I may comment on your response to JL .
I currently email with 4 different Cardiologists at 3 different hospitals ..Some are clients / friends , the others are research at UCSF and my own Cardiologist at Kaiser .

JL is very right on regards his comments on inflammation particularly in regards to coronary artery plaque build up.
I have plaque build up ...not enough for stents ..( I've had a cardiac cath ) ...and Pre flu season every year Kaiser is on me relentlessly about having a flu shot ....why ...as they explain , flu causes inflammation and they are concerned that will cause my arterial plaques to rupture .
So drugs that reduce inflammation for those with known CAD are very much in focus .
Regarding your other comments about TG's around 200 .....every Cardiologist I know will insist you try to lower them by diet and exercise alone . It's only with high risk patients such as myself that are already max'd out on statins where prescriptions are considered.

One can argue with JL about his expectations for stock price , sale of co etc ..but in my experience he is very current on where treatment of CAD ( coronary heart disease ) is going ....and increasingly IMHO it's being focused on the role of inflammation

I do not currently have a position in AMRN , however I am encouraged by todays scrip numbers and may restart a position tomorrow .
GL
Akanz

[jessellivermore]

"with all due respect, I think you are chasing ghosts on the inflammatory angle."

homebuilder...Rest assured the notion that diabetes and atherosclerosis are the result of inflammation is no ghost...You are entitled to your opinion here, but please be reminded, "The speed of light, does not need the defense of opinions."

Also included in your post is a comment to the effect AMRN would be broke by the end of this year...Could you be so kind to explain, using real numbers, how you came to that conclusion. Please include revenue in your estimates...

tia...":>) JL

[mtds]

Inflammation is key reason for successful JELIS study in Japan.Dr.Barry Sears sent me an article from Athero. and Thrombosis Journal published in 2011 by Japanese using JELIS data.It showed Inflammation as measured by AA/EPA ratio. For subgroup of people ,This ratio -EPA/AA dropped from 1.6 to 0.8.
Another article in 2012 using Jelis data showed that DHA is correlated with LDL ,but EPA is not.
Recently Dr.Topol --wrote an Op.ED article about harmful effects of Statins--causing Type 2 diabeties.He felt that high dose of Lipitor,Crestor or Zocor is the cause.He is not rejecting Statins--but feels that caution is required and new approach to reducing LDL,C-RP needs to be looked at.
There ia another product is being developed-but it won't be approved until 2015 or 2016.
Vascepa--is a drug--that reduces trigylcerides and C-RP. Dr.Sears told me that 6 grams/day of EPA would reduce cardiac events based on his research.
You are right--many cardiologists need confirmation from Reduce-It study to prescribe it in large numbers.
Anchor study -in the meantime-is compelling information. Recently--Dr.Sinatra appeared on Dr.OZ show--he is against Statins.He uses TG/HDL ratio as that is convincing to him with definitive studies.
VASCEPA reduces TG and C-RP and AA/EPA ratio--all inflammation indicators.

[mtds]

By he way--I have been taking Lipitor since 1997--now I have Type 2 diabeties for last 5 years.No one in my family has diabeties.
I used high dose to lower my TG. But now I am using Vascepa in addition to lower strength of Lipitor.

[sts66]

JL, with all due respect, I think you are chasing ghosts on the inflammatory angle.

With all due respect to you, I totally disagree. JL is one of the growing number of physicians who are becoming educated about how chronic inflammation is at the root of many, many diseases, and preventing it can prevent the patient from ever developing symptoms, let alone full blown disease. He's posted numerous links to research articles about this, and it's really not new news except for the newer studies - my internist has been preaching this stuff to his patients for over 3 years now. Your typical old fashioned PCP or cardiologist, ones resistant to change in thinking, yeah, I can see them not believing in it - but they will eventually come to our side, the evidence is too powerful to resist.