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exwannabe

03/09/12 9:43 PM

#138530 RE: iwfal #138528

So re-using the originally assumed HR always give a wildly optimistic assumption of chances of success.

Agreed. But it still fits a common mindset.

"The trial was powered as we see fit, some data came in bad, but we maintain our view of the original power assumptions."

Now I see why some of the FTs are set this high. If one is not confident of ones power assumptions (and is not chasing zebras), then 50% could make sense.