Biotech Values

[exwannabe]

So re-using the originally assumed HR always give a wildly optimistic assumption of chances of success.

Agreed. But it still fits a common mindset.

"The trial was powered as we see fit, some data came in bad, but we maintain our view of the original power assumptions."

Now I see why some of the FTs are set this high. If one is not confident of ones power assumptions (and is not chasing zebras), then 50% could make sense.