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dewophile

03/09/11 8:19 AM

#116185 RE: DewDiligence #116184

for HIV they need lifelong therapy - if HIV could be cured in 6 months i bet you wouldn't need a third agent for added protection against resistance
but let me say in general i agree with you re 3 agents - certainly a better chance, i was just saying IF any drugs had a chance in HCV it would be these high barrier to resistance agents
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oc631

03/10/11 4:20 AM

#116252 RE: DewDiligence #116184

Although the viruses themselves are very different, it’s worth noting that Truvada is almost never used by itself in HIV. Truvada is conceptually similar to VRUS’ 2-drug HCV combo insofar as it consists of a purine nuke and a pyrimidine nuke with non-overlapping barriers to resistance.




You fail to mention that Truvada was the SOC in HIV before the release of Atripla.