Although the viruses themselves are very different, it’s worth noting that Truvada is almost never used by itself in HIV. Truvada is conceptually similar to VRUS’ 2-drug HCV combo insofar as it consists of a purine nuke and a pyrimidine nuke with non-overlapping barriers to resistance.
You fail to mention that Truvada was the SOC in HIV before the release of Atripla.