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Replies to #97198 on Biotech Values
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ghmm

06/13/10 8:50 PM

#97214 RE: DewDiligence #97198

Is there a criteria for making the cut on this list?
http://clinicaltrials.gov/ct2/show/study/NCT01132313
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DewDiligence

06/20/10 10:24 PM

#97552 RE: DewDiligence #97198

Who’s Who in All-Oral HCV Programs

[New table format includes columns for dosing frequency, use
of ribavirin, and links to clinicaltrials.gov; added B-I program.]


Protease Other Non-PI Arms w Dosing
Company Inhibitor Compound Class Ribavirin Frequency Link

VRTX Telaprevir VX-222 non-nuke some BID http://clinicaltrials.gov/ct2/show/NCT01080222
Roche ITMN-191 RG7128 nuke none TID/BID http://clinicaltrials.gov/ct2/show/NCT00801255
BMY BMS-650032 BMS-790052 NS5A some BID http://clinicaltrials.gov/ct2/show/NCT01012895
GILD GS9256 GS9190 non-nuke some BID http://clinicaltrials.gov/ct2/show/NCT01072695
B-I BI 201335 BI 207127 non-nuke all TID/BID http://clinicaltrials.gov/ct2/show/NCT01132313
IDIX IDX320 IDX184 nuke TBD qD *

*Drug-drug-interaction study expected to start Jul/Aug 2010.
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mcbio

07/22/10 9:01 AM

#99260 RE: DewDiligence #97198

Re: Who's Who in All-Oral HCV Programs

I think we can now add ACHN to this list with the announcement of the NS5A inhibitor today. ACHN will also share with IDIX the important point of potentially having the only combo with the potential for QD dosing. Obviously, ACH-1625 does not work on all genotypes but the potential is there for ACH-2684 to do so.