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Idahoshaw

12/10/08 2:53 PM

#741 RE: fgnoms #740

fg--the time factor is really referring to the pharmacokinetics of the the drug, not a time factor of convenience for the patient. The million dollar question is: Will there be a decrease in the long term progression of diabetic complications with a combination drug-- 1) will a shortened period of high blood insulin levels decrease long term complications? 2) will more physiologic blood glucose levels reduce long term complications? Current insulin products still leave the patients with these long term complications ( neuropathy, nephropathy, loss of vision, ateriosclerotic cardiovascular disease ) There must be more to preventing complications, than just replacing insulin. Will a combination drug, with improved pharmacokinetics, reduce complications? Thats what the studies are designed to show--hopefully for us and the patients.

More on your hydration comment later.........

Idaho
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Idahoshaw

12/10/08 5:28 PM

#745 RE: fgnoms #740

fg--in my opinion, you have greatly underestimated the market for Hylenex for rehydration. Pediatric rehydration has always been a challenge. When the kids are dry (dehydrated) their veins are collapsed,and it is a noisy challenge to get the IV
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Idahoshaw

12/10/08 5:40 PM

#747 RE: fgnoms #740

fg--in my opinion, you have greatly underestimated the market for Hylenex for rehydration. Pediatric rehydration has always been a challenge. When the kids are dry (dehydrated) their veins are collapsed,and it is a noisy, screaming challenge to get the IV in place--frequently taking 2-3 attempts, sometimes up to 5-10 attempts--at which point the anguished parents either ask "is this necessary" or they just refuse further IV attempts. It is painful for the patient, painful for the parents to watch, and painful for the health care provider put in the position of starting the IV. At that point, all involved will be thrilled with the option of one needle stick with HYLENEX assisted fluid hydration. Once an initial amount of fluid is in, the patient is in a more hydrated state with veins that are no longer collapsed, and an IV if necessary at that time, would be much simpler. ER physicians and nurses will love this simpler mode of rehydration.

Family docs and pediatricians will find it so simple to use that they will use it in the office, rather than sending the patients to the ER for the historic IV,

ER docs will soon see the advantage of HYLENEX for
1--obese patients where it is difficult to start an IV
2--cancer patients whose veins have been destroyed.
3--drug abusers with no veins
4--hepatitis/HIV patients--avoiding a bloody needle stick
5--trauma patients--start multiple HYLENEX infusions in the field
6--combative patients when it is a challenge to get an IV in.

People used to think FAX machines, computers, and cell phones had no future.

It is a great product--be careful about selling it short
Idaho