fg--the time factor is really referring to the pharmacokinetics of the the drug, not a time factor of convenience for the patient. The million dollar question is: Will there be a decrease in the long term progression of diabetic complications with a combination drug-- 1) will a shortened period of high blood insulin levels decrease long term complications? 2) will more physiologic blood glucose levels reduce long term complications? Current insulin products still leave the patients with these long term complications ( neuropathy, nephropathy, loss of vision, ateriosclerotic cardiovascular disease ) There must be more to preventing complications, than just replacing insulin. Will a combination drug, with improved pharmacokinetics, reduce complications? Thats what the studies are designed to show--hopefully for us and the patients.
More on your hydration comment later.........
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