Replies to post #5962 on Entremed (ENMD)

[vk707]

Doc A-1 D.C.

So you have decided to crack the tuff nut!

Have you recieved any reply frum S.G.K.F.?

I wunder whut our science officer has to say 'bout Panzem first, now knowed here locally.. as the "P.F.P.*" program? When did she git herself promoted to Vice President?

Why is it that sum Panzem has made it out the backdoor across the pond,and where is its destination? Who ya gonna calll...The Panzem Police?

Is Panzem Ointment a possibility? Wunder why aint no one contracted for this here idea? Likes Carl Sagan said.."Billions and Billions". In this case jus' sitting in some ones grey matter.

Hit Mobery up fer the postage. The guy is a triple dipper and has too much money. Fargo will all but quarantee he won't say NO.

Lotta questions........

Best to alll,
vk 'n Fargo
Note:PFP* is a registered trademark o' Doc A-1 Enterprises, A Division o' Doc A-1 Inc.

[nottadoc2]

Re Panzem First:
Docaaron your theory is appealing, as the Taxol/Panzem trial info indicates the two products were given "in combination". But given that 2ME2 is metabolized pretty quickly, would the anti-Hif effect wear off or wash out so that the Hif response/chemoresistance effect could recuperate before the Taxol could whack the cells ? Are you suggesting a Panzem-Taxol; Panzem-Taxol, et seq., or or Panzem-Panzem-Panzem, etc., then Taxol-Taxol-Taxol, etc? In either case, how much time between the preceding dose of Panzem and the following dose of Taxol to begin the initial testing ? Could presently known mouse to human data be extrapolated to test these timing issues pretty quickly ?