Entremed (ENMD)

[nottadoc2]

Re Panzem First:
Docaaron your theory is appealing, as the Taxol/Panzem trial info indicates the two products were given "in combination". But given that 2ME2 is metabolized pretty quickly, would the anti-Hif effect wear off or wash out so that the Hif response/chemoresistance effect could recuperate before the Taxol could whack the cells ? Are you suggesting a Panzem-Taxol; Panzem-Taxol, et seq., or or Panzem-Panzem-Panzem, etc., then Taxol-Taxol-Taxol, etc? In either case, how much time between the preceding dose of Panzem and the following dose of Taxol to begin the initial testing ? Could presently known mouse to human data be extrapolated to test these timing issues pretty quickly ?