nottadoc, there is a lot of human trial data on Panzem NCD. Enmd came up with the 4 times per day dose schedule because that keeps the Panzem blood levels at their projected therapeutic levels. T-max is the time until the maximum blood levels are reached. The T-max in the Panzem NCD phase 1b trials was found to be about an hour depending on the dose levels. (However as George pointed out, the glioma trials differ from the phase 1b trials.) I would imagine they could time the Taxol dose so it comes about an hour after a Panzem NCD dose. Of course I don't know Taxol's T-max. Since Taxol is anti-angiogenic at low doses I would imagine you would not have to align the T-max of both drugs. Just start the patient on Panzem NCD first and continue with the 4 times per day dose schedule.
The goal would be to get the patient to the maximum Panzem NCD blood levels before the Taxol is given. Then repeat that before and after each Taxol dose. If for example, Taxol is given once a week then make sure the Panzem blood levels are at their maximum levels before and after giving the Taxol. Keep giving Panzem NCD so that its levels stay in the therapeutic zone. Giving Panzem 4 times a day, the entire week before the next Taxol dose, would not interfere with that strategy.
A schedule could look like this:
PZ,PZ/Taxol,PZ,PZ......PZ(4xdaily).....PZ,PZ/Taxol,PZ,PZ.....>
I would leave the details up to trial doctors as long as they get the Panzem NCD blood levels to their maximum before adding the combo drug and continue that strategy until tumor is gone.
Aaron
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