Replies to post #766913 on NorthWest Biotherapeutics Inc (NWBO)

[Chiugray]

GoodGuyBill, AI search was pretty helpful here. It confirmed to me the link and file is hosted on the NHS website and that it seems to be the "NHS England high cost drugs list 2025-2026" (version 20.0) document.

It seems to confirm what you are saying too:

This indicates:
1. The treatment has been approved, but only under IFR mechanisms, allowing funding on a case-by-case basis.
2. Murcidencel/DCVax-L is listed for tumor-based cancers generally, rather than restricted only to Glioblastoma.
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In the NHS context, it can be funded via IFR for various tumor-based cancers, not restricted to GBM. The decision to fund in a particular case would still depend on clinical justification and approval through the IFR process at the local Clinical Commissioning Group (CCG) or Integrated Care Board (ICB) level.

📌 Key Notes:
- IFR Funding Pathway: Murcidencel/DCVax-L is not routinely commissioned for widespread use across the NHS; it is considered a “Category 4” drug in the list—available via IFR only.
- Tumor-Agnostic Coverage: The listing does not limit it to GBM specifically, meaning it can be requested for other tumor-based cancers where there is a clinical rationale.
- Eligibility: The decision to approve funding would depend on the IFR panel’s assessment of clinical need, cost-effectiveness on a case-by-case basis, and adherence to IFR criteria.

[MarauderWarlock33]

Doc Logic makes a lot of plausible reasoning what and why this IFR for all type of cancers while GBM n rGBM is approve and cover by NHS funding. I believe NHS will try to stream line DCVAX-l approval process for all types of tumor cancers once they confirmed efficacy of DCVAX-l through rolling review of RWE with IFR means. I am very please with this revelation. I remember LG once said DCVX-l being kind of like biological AI which will be essential for all tumor target immunotherapy, ICI, Cat-T...etc. This synergistic combo treatments will accelerate the adoption of DCVAX-l like NVIDA coming out of nowhere becoming a Trillion $ company overnight, but they been a suffering small tech company for over 10 years just like NWBO. I see the resemblance of the two company with the paradigm shifting compounds, one is for medical and the other is GPU. I believe our time is near ! Hang in there for a little longer. LOL.