Why aren't you simply focused on longs winning instead of shorts losing? Shorts are generally institutional, smart, and hedged. They have a rich feed ground here among pre-commercial biopharma companies - then they move on when those companies actually have a marketable product. No big deal. This is the eco-system. You cannot beat the shorts - and that is, to my mind, OK. My investment is about winning to the upside - which is much higher than any gains to the downside over the long run (if Anavex succeeds.)
You seem to think I am rooting for the shorts. I am not. But, I have been in the pre-revenue biopharma game for since my mid-20s and can acknowledge the reality on the ground. It is a fantasy to think that there are huge number of shorts that will "get their comeuppance." Sure, an extremely small retail shorts will lose in a big way, but none of the usual suspects will have more than a tiny scratch (and they will keep their years of gains made to date.)