What are the issues about the JAMA paper? Over 30% occurrence rate of pseudoprogression is real. Do you know what it means? What's the occurrence rate of pseudoprogression in checking point inhibitor? 7%?
JAMA paper tells the medical field that clearly massive and sustainable t-cell infiltration into tumor site is real. See the following figure? DCVax-L in combination with PD1 inhibitor has much better results. For PD1 inhibitor to work, t-cells have to show up at tumor site first. It is so obvious that DCVax-L made tons of t-cells show up in the first place so that PD1 inhibitor can unmask t-cells and let them eliminate cancer cells. Ask your boss to see if I am telling the truth.
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