Replies to post #740271 on NorthWest Biotherapeutics Inc (NWBO)

[DocLee]

Exwannabe, I would wager (if I live long enough) that Temozolide (for certain) and radiotherapy (probably) will be removed from SOC within the next few years because of their deleterious side-effects especially on T-Cell function which is probably hindering the efficacy of DCVax. The removal of those 2 treatment modalities will not only increase the cure rate but will also cut the cost of the treatment significantly.

A Win-Win situation.

[iclight]

Baffling that so many so called longs haven’t even read the trial protocol and understand that every patient in the p3 got chemorad.

[Baxers]

Why do you think I said 'in it's forthcoming combination forms'?

Because in it's forthcoming combinations with Poly-ICLC alone it will render the existing SOC completely redundant. The only thing that will remain from the existing SOC will be the resection and I am willing to bet that by 2028-2030 DCVax-Direct will be replacing at least some resections for less complicated/ early onset GBMs and Gliomas.

Now add in forthcoming (2027-8) off-label (cheap) PD-1 inhibitors and CSFR-1 inhibitors like PLX3397 (Pexidartinib) and you have a treatment that - end-to-end - is still going to be considerably cheaper for anyone involved in footing the bill, not to mention orders of magnitude more efficacious!

If I were a patient with the choice of being fried by radiation & poisoned by chemo or being given a immunotherapeutic cocktail of my own supercharged cells back to me with a vastly lower toxicity profile, a considerably better expected QOL, and much higher chance of survival I would knock down every fuckin door in sight to get the latter! Patient advocacy groups will be doing exactly that!