Replies to post #737545 on NorthWest Biotherapeutics Inc (NWBO)

[antihama]

I think you hit the nail on the head.

You can't be a science guy and completely ignore the elegance of the DCVax platform; unless, of course you are paid to do so!

[iclight]

Numerous oncologists including Stupp have questioned the platform and the P3. They want actual proof of efficacy not the mess the P3 became. They are science guys by any metric.

[exwannabe]

You can't be a science guy and completely ignore the elegance of the DCVax platform; ...

Please tell me how it is any more elegant than all the other ATL-DCs that have been used in trials. They all take the PBMCs from the patient along with the tumor lysate. Differentiate the PBMCs into DCs and then activate/mature them in presence of the tumor lysate.

The only visible distinguishing feature from most I see is that NWBO has been making a single batch and freezing it for the individual doses, while others I have seen (including all UCLA combo trials) make one batch per dose and use fresh. That clearly is an economic improvement for NWBO as there is a huge cost per batch. But far from clear how it compares clinically and hard to believe it works better than fresh.