There are biomarkers that show evidence of Vascepa’s action including hsCRP, LpPLA2, LDL particle size and count, oxidized LDL, triglycerides, AA/EPA, etc. My wife’s Lp(a) was checked and was 16 nmol/L, well under the <75 limit. She’s been on Vascepa for 4 years. Far as I know Lp(a) was not measured in MARINE, ANCHOR, or R-IT.