Replies to post #437476 on Anavex Life Sciences Corp (AVXL)

[georgejjl]

Donepezil (Aricept) was well tolerated, with most adverse events (AEs) considered to be related to the study drug being cholinergic, transient, and mild-to-moderate in severity. However, dose titration may reduce the development of side effects with the higher dose.

How do you titrate donepezil?
Recommended titration rate:
A dose of 10 mg once a day can be administered after patients have been on a daily dose of 5 mg for at least 4 to 6 weeks.
A dose of 23 mg once a day can be administered after patients have been on a dose of 10 mg once daily for at least 3 months.

https://onlinelibrary.wiley.com/doi/10.1111/ane.12386#:~:text=Donepezil%20was%20well%20tolerated%2C%20with,effects%20with%20the%20higher%20dose.

Good luck and GOD bless,