I am simply stating the obvious fact that reducing or even halting decline does not achieve a cognitive improvement over baseline. Nothing more and nothing less, just pure logic and comprehension of a simple sentence.
Change over baseline would however cater for both "reduction in decline" and "cognitive improvement over baseline".
I wonder how a lawyer would express these things in a precise manner so that there could be avoidance of doubt without having to write "for the avoidance of doubt...".
Lol very well said. At first glance your exactly right about what thoughts come to mind when looking at the endpoint but at second glance Dr. Missling appears to be setting us up best to “compare apples to apples”. Let us not forget that no drug has EVER improved a patient with documented Alzheimer’s.