Replies to post #320953 on Anavex Life Sciences Corp (AVXL)

[Jonjones325]

Thanks for the post. Why does peeking reduce the n?

Why can’t the trial still continue with the rest of the patients? I understand there may be some bias if caregivers and doctors know a positive outcome is likely or unlikely.

However, I believe these tests are pretty objective. Knowing the results of the drug doesn’t make an Alzheimer patient remember what they did yesterday.

I guess the main question is, does taking a peek negate the rest of the trial? It seems like you’re saying it does.

Thanks

[Bourbon_on_my_cornflakes]

Ultimately, whatever Dr. Missling decides on timing will be his best decision based on the facts and circumstances. I support him and trust him to do what is best for patients and shareholders.

I get it, basic stats. I also know we had super results for Rett and PDD, far in excess of statistical significance, which reduces risk and would allow earlier peek.

You would not replace Ron Turcotte (Missling) after guiding Secretariat (Anavex 273) to wins in the Kentucky Derby (Rett) and the Preakness (Parkinsons).

You would trust him to guide Secretariat to victory in the big race, the Belmont (alz trial.)

I'm sure Dr. M will take all factors into consideratoin and make his best decision.