Replies to post #184008 on DD Support Board and Research Team

[foxwoodsfan]

It would be of particular interest to understand how many people may have unknowingly contracted COVID and had such mild symptoms (or none whatsoever) that they were never even tested. Would one assume that those people have already built up (or already had) immunity? Wouldn’t it make sense to then test those people for immunity and then take them off the list for vaccination? Is there even a test currently to test for immunity? And what about people that had COVID and recovered, is there any reason for them to be vaccinated?

[12yearplan]

Thanks Dragon, wanted to hear some of the resident experts
Opinion on this campaign that I became aware of recently
That seems to be well situated in the
"Alternative medicine" and anti-vax camp. I have big doubts for.
Although, I had success with two (acupuncture for allergies and oregano oil as antiseptic for a cold coming on or bad taste in da mouth). Shaj seems to come at it from an another angle again.
Thanks again, will look for more of your type of analysis later
Time to get off the computer (sitting is the new cancer apparently ;)
Also, da wife is a "alternative" lifer and may get us killed ;).

[shajandr]

"This so called expert believes vaccines such as the mRNAs will place selective pressure on the Covid virus to mutate."

He is exactly correct. I am bizzy now and will 'splain Moor this weakened. Take this illustrative analogy for now:

If everyone were vaccinated worldwide on the same day and if all vaccinains were nearly 100 percent effective at eliminating coronavirus replications (nott just symptoms or hospitalizations), a vaccine wood eliminate disease. If nott, it won't.

Here's the analogy. When you treat cancer with a chemotherapeutic agent, you generally do so at the highest dose possible based on risk and side effects. You need to kill ALL the cancer cells and quickly. A low dose will allow surviving cells that mutate (cancer cells are highly mutable and Doc can CONfirm are wild and often highly anaplastic with extra and deformed chromosomes, bits of odd DNA all over the genome - in a way like an RNA virus with error prone viral polymerases butt the viral 'chromosme' segments do nott become anaplastic for packaging limitation reasons).

If you treat with a low dose of the chemotherapy agent, all you will do is select for those few variant cancer cells that have some degree of resistance - just like low-level chronic antibiotic has and does lead to antibiotic-resistant strains. These variants become more and more resistant to the chemotherapeutic agent such that you are now swamped with cancer cells that can't be killed by it - even at high doses. In virology, this effect is known as burn-thru - mutant variants burn thru an antiviral and it can become no longer effective.

This is why chemtherapeutics began using cocktails of multiple chemo drugs at the same time. There may be a few mutants that have some resistance to Agent A and others with some resistance to Agent B and some others with resistance to Agent C. Butt statistically it is unlikely to find any cancer cell resistant to all three agents in a naive patient who has never been treated with A, B, or C before.

Viral burnthru of antiviral drugs is why the HIV/AIDS drugs are given as a combination - same reason the cancer chemo drugs are often used as a cocktail when possible (this is much more complex as Doc knows, butt I'll omit that for now).

And this same paradigm applies to pathogenic viruses like SARS-CoV-2. And it applies with or with~OUTT a vaccine. Like influenza, as enuff people develop immunity from infection or vaccination, the flu virus is thereby selected for mutant variants that evade the immunity. This is why you have to gett a new flu shot every year and many years the vax misses the predominant strain.

I hope this help you understand the point that the 'expert' was raising, because he is exactly correct. This will happen with or with~OUTT a vaccine, butt the more people that become immune to the wild-type virus (call it Wuhan), the FASTER the viral evolution occurs because the increased number of people with partial immunity (or even total immunity) to the wildtype provides increasing selective pressure to select variants that evade the wild-type virus-induced immunity.

Perhaps more on this over the weekend unless I go skiing and crap~OUTT from muscle aches.

BTW, "burnthru" is a term we stole from radar jamming. Koog will understand the CONcept of how radar systems can eventually 'burnthru' a jammer. It's nott a perfect comparison, butt we just swiped your term from the radar crowd for our use.

Some virus types (even highly mutable RNA viruses) have very limited windows to create viable mutant variants - those type, UNLIKE coronaviruses and influenza, don't evade immunity - like say measles viruses or similar.

Sadly, coronavirus SARS-CoV-2 seems to have a fairly large playing field for generating mutant variants that are viable - indeed improved for transmissibility as we see from the UK variant and the Brasil-1 variant. So SARS-CoV-2 would seem to have some room to run evolutionarily - like flu butt maybe less fast and perhaps more limited in how big its playing field is. We simply don't know - because it is all new to us. This is nott a well-understood class of viruses (coronaviruses in general and SARS-CoV-2 in specific).