Replies to post #328194 on Amarin Corp Plc (AMRN)

[Whalatane]

Excellent Thx for posting
Kiwi

[sts66]

May not be the detrimental affects of DHA, if there are any - could be that the only EPA/DHA CVOT, STRENGTH, failed because it used a dose of EPA that was too low to show benefit.

[ratna1]

Good Day Hindukush!Glad to see you are still so active with substantive posts giving both meaning and context to an often emotional discussion.
What I do not understand is this:
on this board there are a lot of our members here which are substantial shareholders. I recall a certain plastic surgeon owning in the vicinity of a million shares or so..
I presume that the accumulated share count represented here would well exceed 5% of the total shares outstanding which is substantial. With all the legal experts on board here why not team up and form an activist shareholders interest group that bundles its voting rights to make an impact on company policies?

For instance re: Lovaza - I recall that this argument about the detrimental impact of its EPA/DHA formulation already being a hot topic here for at least 4 years. But how can we have it being brought up on the BoD agenda instead of just churning it here again and again.
Or is it just a convenient way to express pent up frustration on the abysmal performance of the share price.

I admire the action that you and @Marjac and @BioBill have taken to right the wrongs due to Du being conned with false evidence.
Can we get a little more a proactive on other issues also as a united special interest shareholder group with some legal framework to be recognized as a united voting block?

[ratna1]

Good Day Hindukush!Glad to see you are still so active with substantive posts giving both meaning and context to an often emotional discussion.
What I do not understand is this:
on this board there are a lot of our members here which are substantial shareholders. I recall a certain plastic surgeon owning in the vicinity of a million shares or so..
I presume that the accumulated share count represented here would well exceed 5% of the total shares outstanding which is substantial. With all the legal experts on board here why not team up and form an activist shareholders interest group that bundles its voting rights to make an impact on company policies?

For instance re: Lovaza - I recall that this argument about the detrimental impact of its EPA/DHA formulation already being a hot topic here for at least 4 years. But how can we have it being brought up on the BoD agenda instead of just churning it here again and again.
Or is it just a convenient way to express pent up frustration on the abysmal performance of the share price.

I admire the action that you and @Marjac and @BioBill have taken to right the wrongs due to Du being conned with false evidence.
Can we get a little more a proactive on other issues also as a united special interest shareholder group with some legal framework to be recognized as a united voting block?

[rdhitchcock]

Hi HK.......

I am very interested in the upcoming presentation regarding DHA's effects on EPA's benefits. I agree with you that this may explain the lack of benefit in previous trials.

A few years back I re-posted Eliot Brinton's statement at ADCOM. (pretty interesting reading, even looking back today).
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=106405899

This line of his statement stood out to me and for some reason I never forgot it.

Putting in the context -- and again, this has been discussed, but to point out this is the only study at mid-dose EPA, the only study with pure EPA. DHA at best dilutes the effect of EPA. Probably harmful if there's animal evidence that it actually down-regulates the LDL receptor. So I think that's very important.

Would be curious as to what research he was referring to?