Replies to post #333622 on NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

NWBO should get a response from the patent office in about one month.

[eagle8]

Thanks flipper for sharing.

GLTU

[Survivor2012]

Wow, a lot of time and effort to get this done!

[greenJack]

Impressive work/find, both of NWBO as of flipper44

[Basin Street Blues]

Ilkley Moor is in North Yorks BTW

[Basin Street Blues]

You know that find alone should be worth at least +10cents on todays price .....however everyone is exhausted mentally and probably financially.

[Lykiri]

flipper44,

Thank you!

[sukus]

Thanks Flipper for pointing this out about the potentially very important patent.

[vortmaximum]

A whole lot of lawyer-ing going on....

[tryn2]

This board is informative like it is because of the hard work of you and a few others.... thank you flip for that.... the mountains of insightful information you have found has enlightened us all...

[forumreader35]

Good stuff Flipper,

It would seem they are patenting the use of IL-6, -8, -12 and/ or TNFa as markers of sufficiently matured dendritic cells (without need of comparison of immature); versus patent examiner earlier rejected as a comparison for matured vs immatured via IL-8, -12 as markers only

Strength of this would be in whether having these 4 markers analyzed, specifically, is the best bet or another combination is just as sufficient (i.e. there were supposedly 15 markers that can help predict). One would think Northwest picked the best/ most predictive for consistent outcome (that matured dendritic cells in this way were linked with good patient outcome). The fact they are patenting this analysis is great for Direct in that they can optimize for response in future trials (similar benefit of a PD-L1 test prior to PD-1 treatment) - if matured cells in this manner more likely patient's immune system properly trained by their dendritic cells to attack tumor.

[Dr Bala]

Great find, Flip.

[Uranium]

Great find flipper! Is this patent something they’d be waiting for before announcing TLD?

[anders2211]

thanks flipper super interesting good find

[ATLnsider]

Thank you flipper44

[martyDg]

Thanks for the finding. NWBO is definitely busy on both D & L

[Doc logic]

flipper44,

Thanks! One more duck getting into line. Been wondering for a while now when the next steps for this patent application would be made so future trial results don’t get ahead of patent protection. They don’t want to get too specific where the application of tweaks would require more specificity in their patent application which in turn would lead to more competition down the road and knockoffs in countries that do not provide patent protection now. The secret sauce needs to stay the secret sauce as much as possible. Best wishes.