Replies to post #256589 on Anavex Life Sciences Corp (AVXL)

[georgejjl]

Tdeank, I agree.

I loved that glutamate sum of least squares line when I first saw it...almost no residuals...

The US Rett syndrome Part A trial results are AMAZING especially Super Responder Subject 107001

BTW all of the subjects in this Part A cohort improved within just 7 weeks of treatment at a dose of just 5 mg per day

Subject 107001 was a SUPER RESPONDER (see her response below)

RSBQ Total from 59 to 14 in just 7 weeks
RSBQ Hand Behaviours Subscale from 5 to zero in just 7 weeks
RSBQ Breathing Problems Subscale from 9 to 4 in just 7 weeks
% Change in Glutamate 66% reduction from baseline in just 7 week
CSHQ (Sleep) Total 20 in just 7 weeks
Glutamate µmol/L 11 µmol/L of Glutamate in just 7 weeks
% Change CSHQ Waking 1% decrease during the Night in just 7 weeks
% Change in RSBQ Total 76% reduction in just 7 weeks
% Change in GABA 80% increase in just 7 weeks

GABA increases substantially from baseline (VERY GOOD)
Glutamate decreases substantially from baseline (VERY GOOD)

https://www.anavex.com/wp-content/uploads/2019/09/ANAVEX2-73-RS-001-Finland-Conference-Sept-2019-Final.pdf

Good luck and GOD bless,