Thx for pulling quotes these are helpful. However our situation is opposite. Judge trying to make an obviousness statement about A when the data is A and B together showing a reduction in Apo B and has no comparison group to B showing any significance. IF A (epa) reduced Apo B, you would expect a diff between the A and A plus B bc B (estriol) would not be working so the diff between the groups would get larger and significant.