Replies to post #258336 on Amarin Corp Plc (AMRN)

[jessellivermore]

I've read Mori..

Mori was not a Japanese study...but was published in a Nutrition Journal.

It involved 59 patients 56 finished the trial..there were three groups of slightly overweight males.. Trial was double blinded

A) Olive Oil

B) EPA 1.8 gms/day

C) DHA..1.8 gms...


https://academic.oup.com/ajcn/article/71/5/1085/4729166

Results: Fifty-six men aged 48.8 ± 1.1 y completed the study. Relative to those in the olive oil group, triacylglycerols fell by 0.45 ± 0.15 mmol/L (˜20%; P = 0.003) in the DHA group and by 0.37 ± 0.14 mmol/L (˜18%; P = 0.012) in the EPA group. Neither EPA nor DHA had any effect on total cholesterol. LDL, HDL, and HDL2 cholesterol were not affected significantly by EPA, but HDL3 cholesterol decreased significantly (6.7%; P = 0.032). Although HDL cholesterol was not significantly increased by DHA (3.1%), HDL2 cholesterol increased by ˜29% (P = 0.004). DHA increased LDL cholesterol by 8% (P = 0.019). Adjusted LDL particle size increased by 0.25 ± 0.08 nm (P = 0.002) with DHA but not with EPA. EPA supplementation increased plasma and platelet phospholipid EPA but reduced DHA. DHA supplementation increased DHA and EPA in plasma and platelet phospholipids. Both EPA and DHA increased fasting insulin significantly. EPA, but not DHA, tended to increase fasting glucose, but not significantly so.

This is a study published in a Nutrition Journal and not a peer reviewed CVD study...The results were so-so...EPA lowered Trigs to a slightly lesser degree than DHA...EPA lowered HDL and DHA raised HDL2 by 29% while EPA lowered HDL3 significantly (6.7%) Higher HDL would be considered beneficial by many at the time of this study. Interestingly although DHA increased LDL (bad) DHA did increase the LDL-C particle size (which is considered beneficial...While EPA did not increase LDL-C it did not increase LDL-C particle size...So the effect on LDL-C could be considered a tie..This non peer reviewed nutrition study in no way says anything concrete about predicting that EPA would be superior to DHA..Or provides any evidence to support obviousness of EPA in lowering CVD event risk..or even the Marine trial as this would require an apples to oranges comparison...

This judge is either corrupt or lacks the mental skills which a judge needs....

":>) JL

[jessellivermore]

marjac....

Amarin's lawyers should have jumped on the fact that "Mori" was not only not published in "peer reviewed" medical journal It was not published in a medical journal...But rather it was published in a Nutritional Journal. And this would not be considered acceptable by any medical society..Also the study was very slipshod...With 59 male slightly obese males with mildly elevated trigs...The ranges were not given..we know 56 individuals finished the trial, but we know nothing about their ages..whether some were diabetic...whether they had other comorbidities..

In short "Mori" lacked the structure to be considered a valid clinical trial because it lacked information on who were being treated. The FDA would not consider this a valid clinical trial...So Du who is not a physician nor is there any evidence that she has any medical background decides she knows more about this very complicated issue than the experts and feels free to throw out millions of dollars of research and the FDA process and throw them out the window because she determines the results were obvious...The FDA did not think EPA's effects were obvious...they dam sure made the company finish the trial..

This country which my father and my mother died in the service of the army and I went to Vietnam for is going to hell because we have these liberals and leftists...And a bunch of phonies crying social injustice and slinging names around...Well this is the payoff.. Our free loading leaders don't give a dam about how hard we work and how much money we spend on improving medicine...And let these thieving maggots steal away all our hard earned accomplishments..

Nobody has mentioned Trump..He should hear about this...

":>) JL