Replies to post #249039 on NorthWest Biotherapeutics Inc (NWBO)

[sukus]

Gary, I am no expert too, for Direct as the name indicated, the Dendritic cells were not coached or educated to recognize the antigens yet. The cells picked up the antigens of the tumors after “Directly” injected into the tumors. The tumors can be any “types” of solid tumors. The tumors can be “anywhere” in the body.

Oh and these were the secret ingredients that I forgot to mention.
After the process of leukapheresis, the blood was frozen and fedexed to Cognate. At Cognate, they processed the blood through very strict and proprietary procedures to get specific Dendritic Cells which were young and powerful. These processes were patented. These dendritic cells when injected to patients tumors, would mobilize T-cells to recognize tumors antigens or DNAs. Tumors could not hide by pretending they were “friends” anymore. Their existence became so visible in front of T-cells. T-cells attacked the cancers immediately since they are army inside our body. When the wars inside the body happened, the patients felt “fever” or flu like symptoms. With method B of Direct, out of 21 stage 4 patients, 18 were stable as soon as 8 weeks. Wow.

[sukus]

Gary, you are correct. Direct was a paradigm shift since it could render other approaches obsolete. But even though the concept was radical, this approach was not violating nature at all. It works along with nature. Therefore only minor side effects.

“it would seem like a person could go through the procedure once in their life, and have a vaccine that could be used on any cancer provided what they did was properly preserved. “

[survivor1x]

Epitope spread has been observed in provenge. So there is precedent. More rapidly changing tumors appear to be more susceptible to an immune attack because presumably they are more easily identified as a foe.

[sukus]

Gary, I remember you suggested DCVax Direct and L together in combination theraphy. I believe those are brilliant ideas and safe to the patients. Some patients with tumors already spreaded in multiple locations may have the most benefit of the combination theraphy applied. Some patients were already too sick in the beginning so surgery would even weaken the patients considerably, applying Direct first seemed very wise until the patients were strong enough to have the solid tumors operated/removed and subsequently the DCVax-L can be made for the patients.