“Now that trial is close to over, if not over, they are recruiting the younger patients in the larger trial.”
I believe they are still recruiting the 15 patients age 18 - 45 per the protocol on clinicaltrials.gov.
Missling answered Tom Bishop’s question on the CC, that yes total 6 + 15 = 21.
Anavex does not yet as far as I know have go ahead for the larger trial in children with Rett, which Missling also confirmed is still the next part of Rett plan.