Replies to post #197801 on Anavex Life Sciences Corp (AVXL)

[ClosetInvestor]

The response of only 8 patients in an open trial doesn’t seem significant enough to base any claims on.

[Doc328]

This is a non sequitur as the 2a patients did not have actigraphy. They did not even do a sleep diary. Data came from 3 of the 17 questions of the HAM-D depression scale. According to the trial registries, the 2b/3 uses a self reported scale of sleep continuity but not actigraphy.

"The current results suggest that
compared to sleep diaries, actigraphy can offer an attractive
and more reliable alternative for the measurement of signs
and symptoms of disease, or the evaluation of therapeutic
effects. "

From clinicaltrials.gov
"RSCAQ sleep score [ Time Frame: Weeks 0, 4, 12, 24, 36, and 48 ]
To evaluate whether ANAVEX2-73 improves sleep continuity as assessed on a serial basis (weeks 0, 4, 12, 24, 36, and 48) with a questionnaire that assess reported sleep continuity (RSCAQ)"