Replies to post #179042 on Anavex Life Sciences Corp (AVXL)

[Investor2014]

One thing it does point to is that taking and analysing CSF is important.

Good to see that the Anavex P2b/3 study checks for markers in CSF. We can hope that in doing so these various studies are known to those involved with running the trial.

[XenaLives]

Alzheimer's caused by poor blood flow to the brain?

Postulated in this article:

https://medicalxpress.com/news/2018-04-alzheimer-disruptions-brain-energy.html

If true - vaccines don't seem like a good idea to me. The article also discusses BBB.

Excerpt:

The gene associated with the highest risk of developing Alzheimer's disease later in life is called APOE. Everyone inherits two copies of this gene, one from each parent, and APOE exists in three variants (alleles), called e2, e3 and e4. People with two copies of the e4 variant of the gene ("APOE4") increase their risk of developing Alzheimer's disease by about three to five times.

Researchers from John Hopkins University showed that people with the APOE4 gene had reduced brain blood flow, without any symptoms of Alzheimer's disease. And a separate study, using genetically engineered mice with the human APOE genes, showed that APOE4 resulted in damage to the capillaries before any decline in brain-cell activity became evident. These findings support the idea that blood flow disruptions may be one of the earliest changes in Alzheimer's disease.