Replies to post #167254 on Amarin Corp Plc (AMRN)

[chas1232123]

TTE - " a median follow-up of 3ish years is very unlikely to get the HRs we got with a median follow-up of almost 5 years. "

Correct IMO. Good catch, I hadn't thought about that for STRENGTH (I don't worry much about Epanova.) If they're a little bit smart (and best to assume they are), they'll run STRENGTH to completion for several reasons, barring a really lucky statistical fluke in their favor. (There are ways to test for that.)

I expect EPA/DHA blends in sufficient doses have benefit, because fish-eating populations have reduced risk, and they get DHA. The science says you're right that the benefit will be substantially less than for V. Plus, Amarin presumably has applicable patent protection, not to mention a substantial head-start. Not a lot of reason to lose sleep about Epanova IMO.

[invest2992]

my two cents (without deep DD) is that the trial will be halted for futility at the next interim JMO

[jessellivermore]

TTE...

Quote: "That sort of thing might allow 2.2g of EPA to get much closer to the efficacy of the 4g of EPA-EE you get with Vascepa. The possibility has to at least be considered."

Not a chance...It's all just BS...There is no proven increased absorption whether its esterified or in the trig form...Just BS...

"":>) JL

[lowlevelowl88]

TTE, great insights.

As a follow-on to the increased uptake of DHA, this would increase incidence of diarrhea as well, yes? Probably lowering compliance -- perhaps enough to further harm P values?

Also looking back at EVOLVE, can we point to this delivery system as the most likely reason for surprising EPA/AA levels? Or is it only unique to STRENGTH?

[bidmark]

If AZN is aware of your 23.45% estimate on Reduce It, they should be very concerned!

[sts66]

All of the fish oils, like krill, that proclaim greater bioavailability show charts of levels of serum EPA in the hours after taking their pills, but it's a canard - doesn't matter how fast EPA is absorbed, it's how much in total - the area under the curves for EE-EPA is the same, so it matters not whether you have a slowly absorbed or rapidly absorbed type of EPA.