ggwpq -- Baker bros have some solid reputation in healthcare. They do a good home work before investing. I trust their insights and have seen them making more great calls than most of the others funds.. IMO.
Acquainting yourself with The Legendary BAKER BROS AMRN's largest shareholder 13.5% and 40 mln shrs background
IIRC both brothers (one is a Stanford PHD in Immunology and the other was a deal make/Lawyer from First Boston decided to run money.) So back in the early 2000 period BEFORE they opened the fund up to Pension Funds, was bequeathed ~$100 mln to manage strictly in BioTechs from none other than the multi-billionaire NYC's super businessman and major NYC philanthropist Larry Tisch:
Through acquisitions, Tisch built Loews' into a highly profitable conglomerate (with 14 hotels, 67 movie theaters, CNA Financial, Bulova, and Lorillard) with revenues increasing from $100 million in 1970 to more than $3 billion in 1980.[3]
In 2002, the year before Larry Tisch's death, the corporation had revenues of more than $17 billion and assets of more than $70 billion
The Baker Brothers are ACTIVE mgrs(usually have seat(S) on some of their holdings advising mgt and FULLY BioTechs the highest risk of all: NO Big Pharmas in their portfolio AND CONCENTRATED positions despite managing ~$15 BLN now from $100 mln in early 2000 period.The Baker Brothers Fund is the largest fully dedicated Biotech Fund PERIOD.
The above is a FAST rundown.
DIFFERENT STROKES FOR DIFFERENT FOLKS
PS Just happened to see this post and have not looked at postings diligently.
Special Note to North4000 and JesseLivermore: IIRC Sagamo many years back was one of the top ten holdings of The Baker Brothers.