Replies to post #147940 on Anavex Life Sciences Corp (AVXL)

[hnbadger1]

Thanks Bourbon, great update!!

[nidan7500]

Highlights of the shareholder meeting

Great effort...nicely done

[tredenwater2]

Thank you Bourbon. Keep the faith!

Buy!

Tred

[Pazzo1212]

Thank you! Did he mention if the Alzheimer’s trial will start 2H 2018 like the other two?

[rocalinda]

Bourbon,

Thanks for the nice summary. I was able to grab another 10K shares at the discounted price -this is it for me, although I have said that before.

I continue to believe that our patience will be handsomely rewarded. It may take a couple of more years but it all will be worth it in the end.

GLTA who believe.

[poguemahone]

Bourbon:

Thank you for the update of the SH meeting. The only thing that does not make any sense, and perhaps you can enlighten me, is why did the share price hit a 52 week low if there are so many positive developments on the horizon?

1.22 Million shares sold today. I know some on this board will say "but there were also 1.22 Million shares bought"-as if that is supposed to make us feel better. Many of these shares sold are investors or institutions that finally threw in the towel after Missling's latest update, which more or less is "we haven't started a trial yet, but hang in there, it will eventually happen (maybe)."

As much as I try to remain optimistic, it's days like these (after waiting months for updates), that really make this difficult.

One thing does seem correct after today's update--there is no cabal. The reason the price has been falling these past 6 months is explained by this morning's press release. Apparently, some investors were made aware or correctly speculated that the company was not going to be meeting its milestones.

[Biostockclub]

Bourbon,
Thanks for your time and effort put into sharing this update.

Feels like a team effort which is much more comforting than the isolated feeling of investing alone. I believe that at its best, this benefit of shared knowledge, opinions, strategies, even conjecture, when based in substance, whether positive or negative, is a powerful tool for investors and traders alike. The message board is an invaluable forum for information exchange and serves to gauge the many different measures by which this stock is viewed: emotional sentiment, scientific exploration of our compounds, business strategies, investment experience, and so on.

I, for one, am grateful for all of the contributions generously posted. Please keep them coming - the whole is greater than the sum of its parts.

Special thanks to those who attended the meeting and provide first hand impressions for the rest.

That means you, Bourbon! Good man!
And others who report their impressions as well TIA, greatly appreciated,
Biostock

[Fireman02360]

Thanks for the update Bourbon. I have been critical of Missling lately, maybe this sentiment is wrong, I don't know. It was nice to hear that Anavex has filed the IND in Europe for PD....I wasn't expecting this until sometime in the summer. I have a gut Anavex will announce Retts Trial start early, before 2H.....just feels like Missling is being more cautious with time frames and may surprise us all. I repurchased 18,000 shares today, all below $1.91.

Was there any mention of Biogen MTA? Just curious if this was talked about.

I planned on attending the ASM myself but was overly optimistic with my arm surgery and the related healing process. Still in pain and no condition to travel. Thanks for taking taking the time to update us all.

-Fireman

[hapit]

Thanks for info. Any specifics on why Rett IND is not approved by FDA?

[blanka]

Thank you!

AVXL

[falconer66a]

My Take.

Bourbon’s points, from the shareholders’ meeting:

1. Long term users are showing sustained improvement and or stability.

Well, does Anavex 2-73 work, or not? Somebody, quick, find a study showing similar results with any of the four existing Standard of Care Alzheimer’s drugs.

Letting this assertion stand could convince some to think the Anavex story is true. There’s just gotta be a drug keeping early or mid stage Alzheimer’s victims mentally alert after three years of treatment.

2. Specific markers have been found that determine whether or not a patient will respond to Anavex 2-73.

How can this be true? I’ve just read so many postings telling, so authoritatively, that Anavex 2-73 simply doesn’t work; that the Australians continuing to take their doses 3 years after the trial ended down there are just placebo-deceived. No possible biomarkers for Anavex efficacy. Read it here.

3. Stephen Toutain is a key hire...to help the Rett girls.

Very well. Of no contention.

4. ...our tests will be designed to enable AVXL to apply for accelerated approval.

Really? Pretty fine, then. But experts here say such is not possible; that accelerated approvals are not tolerated. Who would know?

5. They have precise data on the optimal effective dose.

How could they? How many experts here have posted that optimal dosing simply didn’t, can’t, or won’t be achieved? The experts here know better, don’t they? Without precise dosings, none of the upcoming clinical trials will have validity. Dosings of neurotropic drugs are tricky, aren’t they?

6. Cash is $28 million, enough to fund the company for 2 years.

I better sell my few shares, then. How can a pharmaceutical survive on only $28 million in the bank?

7. FDA relations are very good.

Na, FDA old-timers are stuck in the last century; gotta have long, old textbook double-blind clinical trials. Have read here how none of the upcoming trials could really work to prove Anavex efficacy, if they can even be put together and conducted.

Anavex talks with FDA, and they talk back? What a thing.



Who am I gonna believe? I think I’ll keep my small AVXL position. No way for me to have attended the shareholder meeting. Thanks, Bourbon, for being there and telling what you heard. More significant than anything I’ve read here for some time.

[powerwalker]

Good morning, Bourbon and JJ:

Great posts and insight from each of you yesterday as to the contents of the ASM and side discussion. All longs are very grateful to your sharing this with them.

While I had many questions reading those posts, most were asked and answered during the course of the day. One though remained that deals with the Aussie trial … per Bourbon:

Missling is highly enthusiastic about the results for alz so far. Long term users are showing sustained improvement and or stability, both of which no other alz drug can do.

Did TGD state that the only the “Strong Responders” are showing improvement wile the others are stable or are most long-term users showing progress? If the later, did he state if each was taking 2-73 only now or on their same regimen throughout?

Once again, “Thank you” to you both for spending the time to attend and reporting back to the board.

P.S. As I am on a “one a day” program, any reply from me will have to wait until tomorrow. Too much Bulleit early this week, influenced my replies to certain naysayers which placed me on a new protocol for the board.