JDM, plus a special note for GJH included (I found an elephant). Maybe some puzzle pieces for bio as well....
I'm not saying there is a real difference in therapy vs transfer, they do both begin with a "T" after all.. The "wording" is interesting.
Why say transfer? It reminded me of "transplant".
Why not just say what it is? Adoptive Cell Therapy?
Every word counts, especially with scientists and lawyers.
I am on new tangents of thought now between "adoptive" and "adaptive"
I'm a meta thinker.
The trail I travel always leads to new ideas....
I just thought about meta thinking...just because and that led me down a path...not sure why but so many paths lead me back to Phosphatidylserine Targeting and Manipulation being the Holy Grail of Medicine.
Of course I had to look up "meta" to see if what I thought it meant was what it meant because I was unsure what it meant but I meant it.
I know...I know...it sounds crazy but it is what it is...
First thing that popped when I searched "meta" was "metaphase" So of course I had to search "metaphase and phosphatidylserine". I see the first entry is from 2002. I love going far back with this stuff.
Biol Pharm Bull. 2002 Oct;25(10):1277-81. Alterations in cell surface phosphatidylserine and sugar chains during apoptosis and their time-dependent role in phagocytosis by macrophages.
Hum Reprod. 1998 May;13(5):1317-24. DNA strand breaks and phosphatidylserine redistribution in newly ovulated and cultured mouse and human oocytes: occurrence and relationship to apoptosis. (the docs I sat next to at Wistar equated cancer to reproductive cells after a quick query made)
Fertilization Induces a Transient Exposure of Phosphatidylserine in Mouse Eggs Claudio A. Curia, Juan I. Ernesto, Paula Stein, Dolores Busso, Richard M. Schultz, Patricia S. Cuasnicu, Débora J. Cohen Published: August 7, 2013http://dx.doi.org/10.1371/journal.pone.0071995
Preferential invasion of mitotic cells by Salmonella reveals that cell surface cholesterol is maximal during metaphase António J. M. Santos, Michael Meinecke, Michael B. Fessler, David W. Holden, Emmanuel Boucrot J Cell Sci 2013 126: 2990-2996; doi: 10.1242/jcs.115253
This increase was due not only to the rise in global cell cholesterol levels along the cell cycle but also to a transient loss in cholesterol asymmetry at the plasma membrane during mitosis. We measured that cholesterol, but not phosphatidylserine, changed from a ~20:80 outer:inner leaflet repartition during interphase to ~50:50 during metaphase, suggesting this was specific to cholesterol and not due to a broad change of lipid asymmetry during metaphase.
One last PDF from 1999 for the heck of it.... phospholipase? Never hoid of it....well now I have. Have I? I have forgotten more than I remember at this point.
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