Avid Bioservices Inc (CDMO)

[asmarterwookie]

JDM, plus a special note for GJH included (I found an elephant). Maybe some puzzle pieces for bio as well....

I'm not saying there is a real difference in therapy vs transfer, they do both begin with a "T" after all.. The "wording" is interesting.

Why say transfer? It reminded me of "transplant".

Why not just say what it is? Adoptive Cell Therapy?

Every word counts, especially with scientists and lawyers.

I am on new tangents of thought now between "adoptive" and "adaptive"

I'm a meta thinker.

The trail I travel always leads to new ideas....

I just thought about meta thinking...just because and that led me down a path...not sure why but so many paths lead me back to Phosphatidylserine Targeting and Manipulation being the Holy Grail of Medicine.

Of course I had to look up "meta" to see if what I thought it meant was what it meant because I was unsure what it meant but I meant it.

I know...I know...it sounds crazy but it is what it is...

First thing that popped when I searched "meta" was "metaphase"
So of course I had to search "metaphase and phosphatidylserine". I see the first entry is from 2002. I love going far back with this stuff.

Biol Pharm Bull. 2002 Oct;25(10):1277-81.
Alterations in cell surface phosphatidylserine and sugar chains during apoptosis and their time-dependent role in phagocytosis by macrophages.

https://www.ncbi.nlm.nih.gov/pubmed/12392078

Hum Reprod. 1998 May;13(5):1317-24.
DNA strand breaks and phosphatidylserine redistribution in newly ovulated and cultured mouse and human oocytes: occurrence and relationship to apoptosis. (the docs I sat next to at Wistar equated cancer to reproductive cells after a quick query made)

https://www.ncbi.nlm.nih.gov/pubmed/9647566

Fertilization Induces a Transient Exposure of Phosphatidylserine in Mouse Eggs
Claudio A. Curia, Juan I. Ernesto, Paula Stein, Dolores Busso, Richard M. Schultz, Patricia S. Cuasnicu, Débora J. Cohen
Published: August 7, 2013http://dx.doi.org/10.1371/journal.pone.0071995

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071995


High resolution detection of uncoated metaphase chromosomes by means of field emission scanning electron microscopy

Cocco L, Gilmour RS, Maraldi NM, Martelli AM, Papa S, Manzoli FA (1985) Increase of globin RNA synthesis induced by phosphatidylserine liposomes in isolated erythroleukemic cell nuclei. Morphological and functional features. Biol Cell 54:49–56

http://link.springer.com/article/10.1007/BF00362283

GJH FOR YOU...>>>

Preferential invasion of mitotic cells by Salmonella reveals that cell surface cholesterol is maximal during metaphase
António J. M. Santos, Michael Meinecke, Michael B. Fessler, David W. Holden, Emmanuel Boucrot
J Cell Sci 2013 126: 2990-2996; doi: 10.1242/jcs.115253

This increase was due not only to the rise in global cell cholesterol levels along the cell cycle but also to a transient loss in cholesterol asymmetry at the plasma membrane during mitosis. We measured that cholesterol, but not phosphatidylserine, changed from a ~20:80 outer:inner leaflet repartition during interphase to ~50:50 during metaphase, suggesting this was specific to cholesterol and not due to a broad change of lipid asymmetry during metaphase.

http://jcs.biologists.org/content/126/14/2990

One last PDF from 1999 for the heck of it.... phospholipase? Never hoid of it....well now I have. Have I? I have forgotten more than I remember at this point.

http://www.jbc.org/content/274/16/11053.full.pdf

NOW, SHOW ME THE MONEY

and

WOOK
IT
UP
BABY!



wook