Replies to post #89677 on Amarin Corp Plc (AMRN)

[jessellivermore]

Error...

"The annual event rate in the JELIS placebo arm was 2.3%.."

Should read .."the annual event rate in the JELIS secondary prevention placebo arm was 2.3% annual..

":>) JL

[Whalatane]

JL the annual event rate ( JELIS secondary ) was

895 PTCA or CABG patients .....placebo arm was 4.8% annual rate
1050 Prior MI patients ..... placebo arm was 4.36% annual rate

The placebo arm was on low dose Simavastatin and with high fish diet that equalled 2gms of serum EPA.

Adding 1.8 gms of EPA , active arm dose reduced the CV events to
3.2% annually ( PTCA and CABG )
and to 3.26% annually in the prior MI cohort.

So the nett effect is that 2 gms of EPA = roughly 26% reduction in events ...in these cohorts .

I maintain that lowering LDL from 178 to 90 on high dose , high intensity Statins , will have roughly the same effect ( Hs CRP etc will also be further lowered ) as these JELIS patients with LDL at 178 plus 2 gms serum EPA

So we are then left with the net effect of 2gms of EPA .......
So in R-IT , Optimal dose Statins plus 4gms of EPA reduces events by at most 26% more then Optimal dose Statins alone in the highest risk patients.
The event rates will be lower in both arms of the Unstable Angina Cohort ...so net/ net...combing all cohorts ...around a 18%-20% reduction in MACE with 4 gms of EPA added to optimal Statin dose.

A 20% reduction would be huge news

JMO
Kiwi