The annual event rate in the JELIS placebo arm was 2.3%...Look it up..
Much ado is directed to the "angina" effect...A couple of points here..First of all as far as CVD events in JELIS..Angina was not considered an event...Only unstable angina was deemed a CVD event..
Unstable angina falls under the ACS (acute coronary synrdrome) definition. Unstable angina is very serious...
As a matter of fact in JELIS the incidence of unstable angina was twice as high as fatal and non fatal heart attacks...Not like there was a ten to one ratio..
As far as your 2903 patients having angina, that was not their sole affliction..Two thirds of those had other conditions such as previous MIs, or previous coronary surgery...There's going to be a lot of folks with angina (and other conditions in R-I, you want to break out your angina argument for R-I guys too) seems like the risk is well matched.