Replies to post #89530 on Amarin Corp Plc (AMRN)

[Pyrrhonian]

HD, or anybody else, where do you all keep getting your 4.8 composite rate from? Looks like some sloppy assumption.

TIA

[Whalatane]

Gabor ...an example of the criticism of I-IT trial

Randall Mark Zusman, MD: "The guidelines, although also controversial, really focus on supporting the clinical trials conducted to date that have emphasized the use of maximal lipid-lowering therapies. And this trial doesn't really address that question, because it's a study of submaximal statin therapy versus submaximal statin therapy with an augmented cholesterol-lowering drug.

I think that my major concern or criticism of this study was it wasn't maximal statin therapy versus maximal statin therapy plus ezetimibe.

Given that the guidelines currently recommend maximal statin dosages or maximum lipid-lowering dosages, they're not talking about 40 mg of simvastatin, a modest dose of a modestly effective statin.

This study emphasizes the importance of lowering LDL cholesterol further than modest cholesterol lowering therapies, but doesn't address the question that has been reviewed and recommendations from the AHA/ACC panel."

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With your powers of DD I'm sure you can find more ...:-)

JELIS was sub optimal use of Statins
R-IT will be optimal use of Statins ...often with max dose of the highest intensity Statins

Kiwi