The blinded crossover protocol works by treating any progresser as "new" DCVAX-L candidate,
Thus, even the patient already on DCVAX-L will start with a new dosing schedule at that time,
I will speculate that the reason for this blinding is to avoid a self selection bias on crossover that would otherwise significantly mask the OS benefit. [There is still of course some confounding of OS due to X-over, but less than if it was done unblinded]
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