Replies to post #238389 on Avid Bioservices Inc (CDMO)

[biopharm]

I just started with GRC, Stony Brook and Helena Paidassi and going back again to how important Brookhaven Lab is and I am now 100% certain that this group is one of the collaborators... they have to be, because if not... it could have turned into a National Security issue and dig deeper, the largest academic user is Stony Brook ==> exactly where Allison Stopeck landed and brought into the mix where she will have access to data, equipment..etc to truly be part of the Translation

1) Brookhaven National Lab basics
2) Alison Stopeck lured over to Stony Brook re: Translational Research and access to the best equipment, data..etc
3) BNL operated by Brookhaven Science Associates
4) BSA Board Members.... and now we have enough puzzle pieces to continue this journey, because Alison Stopeck did not just show up on the front steps of Stony Brook for no reason at all... just like there was not an initiative for CSM Clinical Supplies Management in Fargo ND with ex-Bristol Myers Squibb CEO Gerald Finken being part of the company that sabotaged Peregrine Pharmaceuticals.
5) Helena Paidassi ..part of 2011 GRC event
6) 2015 GRC sponsored by Peregrine/NIH
7) C1q => BINDS PS

https://www.researchgate.net/publication/247183928_C1q_binds_phosphatidylserine_and_likely_acts_as_an_early_bridging_molecule_in_apoptotic_cell_recognition_and_clearance

-------------

Abstract

receptor activity is directly modulated by glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a protein with many nonglycolytic moonlighting functions. In addition to playing a role in the phosphorylation of the receptor, GAPDH may also participate in proper receptor trafficking to the plasma membrane. We previously showed that volatile anesthetics affect GAPDH structure and function that may contribute to the manner by which GAPDH modulates the receptor. In the current study, GAPDH interacted with engineered phospholipid-containing vesicles, preferring association with phosphatidylserine over phosphatidylcholine. Phosphatidyl-serine is known to participate in membrane trafficking of transport proteins and to play a role in receptor stability and function. We observed that GAPDH promoted the self-association and fusion of phosphatidyl-serine-rich vesicles as well as decreased membrane fluidity. Isoflurane enhanced each of these GAPDH-mediated events. Isoflurane also increased the binding of GAPDH to the cytoplasmic loop of the receptor. These observations are consistent with the working model of isoflurane playing a role in the trafficking of membrane proteins. This study is the first to implicate GAPDH and isoflurane in the regulation of receptor localization, providing insight into the mechanism of action of anesthesia.

http://www.hindawi.com/journals/isrn/2012/970795/

[biopharm]

7) C1q => BINDS PS

C1q....hmmm, gives us our oceans of exploration into PS Targeting...

"We generated a large Mytilus transcriptome database from different tissues of immune challenged and stress treated individuals from the Baltic Sea using 454 pyrosequencing. Phylogenetic comparison of orthologous groups of 23 species demonstrated the basal position of lophotrochozoans within protostomes. The investigation of immune related transcripts revealed a complex repertoire of innate recognition receptors and downstream pathway members including transcripts for 27 toll-like receptors and 524 C1q domain containing transcripts. NOD-like receptors on the other hand were absent. We also found evidence for sophisticated TNF, autophagy and apoptosis systems as well as for cytokines. Gill tissue and hemocytes showed highest expression of putative immune related contigs and are promising tissues for further functional studies. Our results partly contrast with findings of a less complex immune repertoire in ecdysozoan and other lophotrochozoan protostomes. We show that bivalves are interesting candidates to investigate the evolution of the immune system from basal metazoans to deuterostomes and protostomes and provide a basis for future molecular work directed to immune system functioning in Mytilus."

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033091

MPS or NGS Next Generation Sequencing will open up many more doors due to analyzing hundreds of new biomarkers and crime labs all over the world will upgrade to new equipment and hopefully Peregrine is keeping tabs of all groups that will be digging deeper into PS Targeting

[biopharm]

I just started with GRC, Stony Brook and Helena Paidassi and going back again to how important Brookhaven Lab is and I am now 100% certain that this group is one of the collaborators... they have to be, because if not... it could have turned into a National Security issue and dig deeper, the largest academic user is Stony Brook ==> exactly where Allison Stopeck landed and brought into the mix where she will have access to data, equipment..etc to truly be part of the Translation ...

I heard Alison Stopeck and figured some may want to review those puzzle pieces ...

Stony Brook #1 academic user of Brookhaven National Lab....and a very likely collaborator with Peregrine Pharmaceuticals....

Hmmmm....or a competitor that needed to extract Dr Stopeck to the dark side

....hmmmm, I do look forward to MRI based biomarkers
https://www.researchgate.net/profile/Renu_Stephen