Avid Bioservices Inc (CDMO)

[biopharm]

7) C1q => BINDS PS

C1q....hmmm, gives us our oceans of exploration into PS Targeting...

"We generated a large Mytilus transcriptome database from different tissues of immune challenged and stress treated individuals from the Baltic Sea using 454 pyrosequencing. Phylogenetic comparison of orthologous groups of 23 species demonstrated the basal position of lophotrochozoans within protostomes. The investigation of immune related transcripts revealed a complex repertoire of innate recognition receptors and downstream pathway members including transcripts for 27 toll-like receptors and 524 C1q domain containing transcripts. NOD-like receptors on the other hand were absent. We also found evidence for sophisticated TNF, autophagy and apoptosis systems as well as for cytokines. Gill tissue and hemocytes showed highest expression of putative immune related contigs and are promising tissues for further functional studies. Our results partly contrast with findings of a less complex immune repertoire in ecdysozoan and other lophotrochozoan protostomes. We show that bivalves are interesting candidates to investigate the evolution of the immune system from basal metazoans to deuterostomes and protostomes and provide a basis for future molecular work directed to immune system functioning in Mytilus."

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033091

MPS or NGS Next Generation Sequencing will open up many more doors due to analyzing hundreds of new biomarkers and crime labs all over the world will upgrade to new equipment and hopefully Peregrine is keeping tabs of all groups that will be digging deeper into PS Targeting