Avid Bioservices Inc (CDMO)

[biopharm]

I just started with GRC, Stony Brook and Helena Paidassi and going back again to how important Brookhaven Lab is and I am now 100% certain that this group is one of the collaborators... they have to be, because if not... it could have turned into a National Security issue and dig deeper, the largest academic user is Stony Brook ==> exactly where Allison Stopeck landed and brought into the mix where she will have access to data, equipment..etc to truly be part of the Translation

1) Brookhaven National Lab basics
2) Alison Stopeck lured over to Stony Brook re: Translational Research and access to the best equipment, data..etc
3) BNL operated by Brookhaven Science Associates
4) BSA Board Members.... and now we have enough puzzle pieces to continue this journey, because Alison Stopeck did not just show up on the front steps of Stony Brook for no reason at all... just like there was not an initiative for CSM Clinical Supplies Management in Fargo ND with ex-Bristol Myers Squibb CEO Gerald Finken being part of the company that sabotaged Peregrine Pharmaceuticals.
5) Helena Paidassi ..part of 2011 GRC event
6) 2015 GRC sponsored by Peregrine/NIH
7) C1q => BINDS PS

https://www.researchgate.net/publication/247183928_C1q_binds_phosphatidylserine_and_likely_acts_as_an_early_bridging_molecule_in_apoptotic_cell_recognition_and_clearance

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Abstract

receptor activity is directly modulated by glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a protein with many nonglycolytic moonlighting functions. In addition to playing a role in the phosphorylation of the receptor, GAPDH may also participate in proper receptor trafficking to the plasma membrane. We previously showed that volatile anesthetics affect GAPDH structure and function that may contribute to the manner by which GAPDH modulates the receptor. In the current study, GAPDH interacted with engineered phospholipid-containing vesicles, preferring association with phosphatidylserine over phosphatidylcholine. Phosphatidyl-serine is known to participate in membrane trafficking of transport proteins and to play a role in receptor stability and function. We observed that GAPDH promoted the self-association and fusion of phosphatidyl-serine-rich vesicles as well as decreased membrane fluidity. Isoflurane enhanced each of these GAPDH-mediated events. Isoflurane also increased the binding of GAPDH to the cytoplasmic loop of the receptor. These observations are consistent with the working model of isoflurane playing a role in the trafficking of membrane proteins. This study is the first to implicate GAPDH and isoflurane in the regulation of receptor localization, providing insight into the mechanism of action of anesthesia.

http://www.hindawi.com/journals/isrn/2012/970795/