>Do you (or anyone else) know if troponin levels are usually measured in clinical trials , paricularly cancer trials?<
I do know that they were following it in the avastin trials. I would venture to guess that it is monitored in all clinical trials, since the test itself is easily completed from drawn blood.
>and that a risk/benefit calculation might favor the treatment as long as the damage is transient and/or reversible.<
Fully agree. Certain anthracyclines have documented effects on the heart, and are administered to a point where the risk / reward is deemed advantageous. The only special consideration to cardiotoxicity is that the heart doesn't heal itself well, if at all. So it's a slightly different framework when compared to AEs like neutropenia that can be well managed / reversed.
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