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BonelessCat

10/22/14 2:03 PM

#74494 RE: thefamilyman #74491

Dose increases range from 25% to 100% and generally 25%, 33%, 50%, 66% and 75%. 75% increases are rare as are 100% occurring mostly during the early cohorts in a drug escalation.

If no AEs on cohort 9 then the next level would be 435, 460, or 525 where 525 is a 50% increase.