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Replies to #27294 on Biotech Values
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DewDiligence

04/18/06 9:17 AM

#27296 RE: kcalt #27294

Re: IDIX HCV milestones

>the license agreement in the 10-k is worded poorly then<

I inferred that there were sales-based milestones from the fact that there are five unspecified milestones (with redacted amounts) specified in the 10K:

http://www.sec.gov/Archives/edgar/data/1093649/000095013506001630/b58494ipexv10w14.txt
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Milestone Event for HCV Products

(A) Data from a Phase I/IIA Clinical Trial demonstrates US$25 million that NM-283 is safe and effective. (The Parties acknowledge that this amount has been paid prior to the Amendment Effective Date.)

(B) [**] $[**]

(C) [**] $[**]

(D) [**] $[**]

(E) [**] $[**]

(F) [**] $[**]
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Normally, you don’t see this many milestone steps for regulatory milestones alone for a single compound; however, after rereading IDIX’s 3/29/06 PR, I agree with you that the $455M comes entirely from regulatory milestones. Thank you for pointing out the error.

This doesn’t change my view that the HBV market alone will support a considerably higher stock price and that anything IDIX achieves in the HCV market is icing on the cake. Regards, Dew
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DewDiligence

05/29/06 8:16 PM

#29326 RE: kcalt #27294

Goldman Sachs excerpt on IDIX
from 5/18/06 (c/o quidditch on SI).
Makes an interesting companion
read with #msg-11329859.

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We continue to expect FDA decision on Telbivudine for HBV ($0.5B) in late 2006 [the PDUFA date is in October]. …We estimate the sales potential is over $0.5B worldwide. [This is an extremely conservative forecast; they presumably mean the U.S.+Western Europe (rather than worldwide) because NVS owns the rights to Telbivudine elsewhere.]

Assuming an industry sales multiple of 5X, peak sales of $0.5B in 2010, 50% share with Novartis and 15% discount rate, the present value of Telbivudine is about $13.40/share. [This excludes the sizable amount of cash on hand as well as the value of the NM283 program in HCV, which could be worth as much as $500M in clinical (start of phase-3) and regulatory milestones.]
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